History of painting

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Pre-history

Main article: Prehistoric art

Cave Painting tall clear glass vase

Rock Shelters of Bhimbetka, rock painting, Stone Age, India crystal sugar bowl

Lascaux, Horse decorative glass bowl

Eland, rock painting, Drakensberg, South Africa

Lascaux, Bulls and Horses

Spanish cave painting of Bulls

Petroglyphs, from Sweden, Nordic Bronze Age (painted)

Pictographs from the Great Gallery, Canyonlands National Park, Horseshoe Canyon, Utah, c. 1500 BCE

The oldest known paintings are at the Grotte Chauvet in France, claimed by some historians to be about 32,000 years old. They are engraved and painted using red ochre and black pigment and show horses, rhinoceros, lions, buffalo, mammoth or humans often hunting. There are examples of cave paintings all over the worldn France, India, Spain, Portugal, China, Australia etc. Various conjectures have been made as to the meaning these paintings had to the people that made them. Prehistoric men may have painted animals to "catch" their soul or spirit in order to hunt them more easily or the paintings may represent an animistic vision and homage to surrounding nature, or they may be the result of a basic need of expression that is innate to human beings, or they could have been for the transmission of practical information.

In Paleolithic times, the representation of humans in cave paintings was rare. Mostly, animals were painted, not only animals that were used as food but also animals that represented strength like the rhinoceros or large Felidae, as in the Chauvet Cave. Signs like dots were sometimes drawn. Rare human representations include handprints and half-human / animal figures. The Chauvet Cave in the Ardche Departments of France contains the most important preserved cave paintings of the Paleolithic era, painted around 31,000 BC. The Altamira cave paintings in Spain were done 14,000 to 12,000 BC and show, among others, bisons. The hall of bulls in Lascaux, Dordogne, France, is one of the best known cave paintings from about 15,000 to 10,000 BC.

If there is meaning to the paintings, it remains unknown. The caves were not in an inhabited area, so they may have been used for seasonal rituals. The animals are accompanied by signs which suggest a possible magic use. Arrow-like symbols in Lascaux are sometimes interpreted as calendar or almanac use. But the evidence remains inconclusive. The most important work of the Mesolithic era were the marching Warriors, a rock painting at Cingle de la Mola, Castelln, Spain dated to about 7,000 to 4,000 BC. The technique used was probably spitting or blowing the pigments onto the rock. The paintings are quite naturalistic, though stylized. The figures are not three-dimensional, even though they overlap

The earliest known Indian paintings (see section below) were the rock paintings of prehistoric times, the petroglyphs as found in places like the Rock Shelters of Bhimbetka, (see above) and some of them are older than 5500 BC. Such works continued and after several millennia, in the 7th century, carved pillars of Ajanta, Maharashtra state present a fine example of Indian paintings, and the colors, mostly various shades of red and orange, were derived from minerals.

Eastern painting

East Asian painting

See also Chinese painting, Japanese painting, Korean painting.

Paintings on tile of guardian spirits donned in Chinese robes, from the Han Dynasty (202 BC 220 AD)

Luoshenfu, by Gu Kaizhi (344-406 AD), Chinese

Emperor Sun Quan in the Thirteen Emperors Scroll and Northern Qi Scholars Collating Classic Texts, by Yan Liben (c. 600-673 AD), Chinese

Eighty-Seven Celestials, by Wu Daozi (685-758), Chinese

Portrait of Night-Shining White, by Han Gan, 8th century, Chinese

Spring Outing of the Tang Court, by Zhang Xuan, 8th century, Chinese

Paradise of the Buddha Amitabha, 8th century, Chinese

Ladies making silk, a remake of an 8th century original by Zhang Xuan by Emperor Huizong of Song, early 12th century, Chinese

An illustrated sutra from the Nara period, 8th century, Japanese

Ladies Playing Double Sixes, by Zhou Fang (730-800 AD), Chinese

Yard concert, 10th century, Chinese

The Xiao and Xiang Rivers, by Dong Yuan (c. 934-962 AD), Chinese

Court portrait of Emperor Shenzong of Song (r. 1067-1085), Chinese

Golden Pheasant and Cotton Rose, by Emperor Huizong of Song (r.1100-1126 AD), Chinese

Listening to the Guqin, by Emperor Huizong of Song (1100-1126 AD), Chinese

Children Playing, by Su Han Chen, c. 1150, Chinese

Chinese, anonymous artist of the 12th century Song Dynasty

Portrait of the Zen Buddhist Wuzhun Shifan, 1238 AD, Chinese

Ma Lin, 1246 AD, Chinese

A Man and His Horse in the Wind, by Zhao Mengfu (1254-1322 AD), Chinese

Shukei-sansui (Autumn Landscape), Sesshu Toyo, (1420-1506), Japanese

A White-Robed Kannon, Bodhisattva of Compassion, by Kan Motonobu (1476-1559), Japanese

Mother Dog, Yi Am (1499-?), Korean

Landscape painting in the shan shui style, 16th century, Chinese

Nanban ships arriving for trade in Japan, 16th century, Japanese

A screen painting depicting people playing Go, by Kan Eitoku (1543-1590), Japanese

Pine Trees, six sided screen, by Hasegawa Tohaku (1539-1610), Japanese

Night Revels, a Song Dynasty remake of a 10th century original by Gu Hongzhong.

Scroll calligraphy of Bodhidharma, en points directly to the human heart, see into your nature and become Buddha, Hakuin Ekaku (1686 to 1769), Japanese

Hanging scroll 1672, Kan Tany, (1602-1674), Japanese

Peonies, by Yun Shouping (1633-1690), Chinese

Genji Monogatari, by Tosa Mitsuoki (16171691), Japanese

View of Geumgang, Jeong Seon (16761759), 1734, Korean

Ike no Taiga, (1723-1776), Fish in Spring, Japanese

Maruyama school, Pine, Bamboo, Plum, six-fold screen, Maruyama kyo (17331795), Japanese

A Cat and a Butterly, Kim Hong-do (1745-?), 18th century, Korean

A Boat Ride, Shin Yun-bok (1758-?), 1805, Korean

Rimpa school, "Autumn Flowers and Moon," Sakai Hoitsu, (1761-1828), Japanese

A tanuki (raccoon dog) as a tea kettle, by Katsushika Hokusai (17601849), Japanese

A House amongst Apricot Trees, Jo Hee-ryong (1797-1859), Korean

Katsushika Hokusai, The Dragon of Smoke Escaping from Mt Fuji, Japanese

Miyagawa Issh, untitled Ukiyo-e painting, Japanese

Tomioka Tessai, (1837-1924), Nihonga style, Two Divinities Dancing, 1924, Japanese

Ogura Yuki, (1895-2000), Bathing Women, Nihonga style, 1938, Japanese

A Chinese painted jar from the Western Han Era (202 BCE 9 CE)

China, Japan and Korea have a strong tradition in painting which is also highly attached to the art of calligraphy and printmaking (so much that it is commonly seen as painting). Far east traditional painting is characterized by water based techniques, less realism, "elegant" and stylized subjects, graphical approach to depiction, the importance of white space (or negative space) and a preference for landscape (instead of human figure) as a subject. Beyond ink and color on silk or paper scrolls, gold on lacquer was also a common medium in painted East Asian artwork. Although silk was a somewhat expensive medium to paint upon in the past, the invention of paper during the 1st century AD by the Han court eunuch Cai Lun provided not only a cheap and widespread medium for writing, but also a cheap and widespread medium for painting (making it more accessible to the public).

The ideologies of Confucianism, Daoism, and Buddhism played important roles in East Asian art. Medieval Song Dynasty painters such as Lin Tinggui and his Luohan Laundering (housed in the Smithsonian Freer Gallery of Art) of the 12th century are excellent examples of Buddhist ideas fused into classical Chinese artwork. In the latter painting on silk (image and description provided in the link), bald-headed Buddhist Luohan are depicted in a practical setting of washing clothes by a river. However, the painting itself is visually stunning, with the Luohan portrayed in rich detail and bright, opaque colors in contrast to a hazy, brown, and bland wooded environment. Also, the tree tops are shrouded in swirling fog, providing the common "negative space" mentioned above in East Asian Art.

In Japonisme, late 19th century artists like the Impressionists, Van Gogh, Henri de Toulouse-Lautrec and Whistler admired traditional Japanese Ukiyo-e artists like Hokusai and Hiroshige and their work was influenced by it.

Panorama of Along the River During Qing Ming Festival, 18th century remake of a 12th century original by Chinese artist Zhang Zeduan Note: scroll starts from the right

Chinese painting

Main article: Chinese painting

Further information: History of Chinese art, Tang Dynasty art, and Ming Dynasty painting

Spring Morning in the Han Palace, by Ming-era artist Qiu Ying (14941552 AD)

The earliest (surviving) examples of Chinese painted artwork date to the Warring States Period (481 - 221 BC), with paintings on silk or tomb murals on rock, brick, or stone. They were often in simplistic stylized format and in more-or-less rudimentary geometric patterns. They often depicted mythological creatures, domestic scenes, labor scenes, or palatial scenes filled with officials at court. Artwork during this period and the subsequent Qin Dynasty (221 - 207 BC) and Han Dynasty (202 BC - 220 AD) was made not as a means in and of itself or for higher personal expression. Rather artwork was created to symbolize and honor funerary rights, representations of mythological deities or spirits of ancestors, etc. Paintings on silk of court officials and domestic scenes could be found during the Han Dynasty, along with scenes of men hunting on horseback or partaking in military parade. There was also painting on three dimensional works of art on figurines and statues, such as the original-painted colors covering the soldier and horse statues of the Terracotta Army. During the social and cultural climate of the ancient Eastern Jin Dynasty (316 - 420 AD) based at Nanjing in the south, painting became one of the official pastimes of Confucian-taught bureaucratic officials and aristocrats (along with music played by the guqin zither, writing fanciful calligraphy, and writing and reciting of poetry). Painting became a common form of artistic self-expression, and during this period painters at court or amongst elite social circuits were judged and ranked by their peers.

The Sakyamuni Buddha, by Zhang Shengwen, 11731176 AD, Song Dynasty period.

The establishment of classical Chinese landscape painting is accredited largely to the Eastern Jin Dynasty artist Gu Kaizhi (344 - 406 AD), one of the most famous artists of Chinese history. Like the elongated scroll scenes of Kaizhi, Tang Dynasty (618 - 907 AD) Chinese artists like Wu Daozi painted vivid and highly detailed artwork on long horizontal handscrolls (which were very popular during the Tang), such as his Eighty Seven Celestial People. Painted artwork during the Tang period pertained the effects of an idealized landscape environment, with sparse amount of objects, persons, or activity, as well as monochromatic in nature (example: the murals of Price Yide's tomb in the Qianling Mausoleum). There were also figures such as early Tang-era painter Zhan Ziqian, who painted superb landscape paintings that were well ahead of his day in portrayal of realism. However, landscape art did not reach greater level of maturity and realism in general until the Five Dynasties and Ten Kingdoms period (907 - 960 AD). During this time, there were exceptional landscape painters like Dong Yuan (refer to this article for an example of his artwork), and those who painted more vivid and realistic depictions of domestic scenes, like Gu Hongzhong and his Night Revels of Han Xizai.

Loquats and Mountain Bird, anonymous artist of the Southern Song Dynasty; paintings in leaf album style such as this were popular in the Southern Song (11271279).

During the Chinese Song Dynasty (960 - 1279 AD), not only landscape art was improved upon, but portrait painting became more standardized and sophisticated than before (for example, refer to Emperor Huizong of Song), and reached its classical age maturity during the Ming Dynasty (1368 - 1644 AD). During the late 13th century and first half of the 14th century, Chinese under the Mongol-controlled Yuan Dynasty were not allowed to enter higher posts of government (reserved for Mongols or other ethnic groups from Central Asia), and the Imperial examination was ceased for the time being. Many Confucian-educated Chinese who now lacked profession turned to the arts of painting and theatre instead, as the Yuan period became one of the most vibrant and abundant eras for Chinese artwork. An example of such would be Qian Xuan (12351305 AD), who was an official of the Song Dynasty, but out of patriotism, refused to serve the Yuan court and dedicated himself to painting. Examples of superb art from this period include the rich and detailed painted murals of the Yongle Palace , or "Dachunyang Longevity Palace", of 1262 AD, a UNESCO World Heritage site. Within the palace, paintings cover an area of more than 1000 square meters, and hold mostly Daoist themes. It was during the Song Dynasty that painters would also gather in social clubs or meetings to discuss their art or others' artwork, the praising of which often led to persuasions to trade and sell precious works of art. However, there were also many harsh critics of others art as well, showing the difference in style and taste amongst different painters. In 1088 AD, the polymath scientist and statesman Shen Kuo once wrote of the artwork of one Li Cheng, who he criticized as follows:

...Then there was Li Cheng, who when he depicted pavilions and lodges amidst mountains, storeyed buildings, pagodas and the like, always used to paint the eaves as seen from below. His idea was that 'one should look upwards from underneath, just as a man standing on level ground and looking up at the eaves of a pagoda can see its rafters and its cantilever eave rafters'. This is all wrong. In general the proper way of painting a landscape is to see the small from the viewpoint of the large...just as one looks at artificial mountains in gardens (as one walks about). If one applies (Li's method) to the painting of real mountains, looking up at them from below, one can only see one profile at a time, and not the wealth of their multitudinous slopes and profiles, to say nothing of all that is going on in the valleys and gorges, and in the lanes and courtyards with their dwellings and houses. If we stand to the east of a mountain its western parts would be on the vanishing boundary of far-off distance, and vice-versa. Surely this could not be called a successful painting? Mr. Li did not understand the principle of 'seeing the small from the viewpoint of the large'. He was certainly marvelous at diminishing accurately heights and distances, but should one attach such importance to the angles and corners of buildings?

Emperor Qianlong Practicing Calligraphy, mid-18th century.

Although high level of stylization, mystical appeal, and surreal elegance were often preferred over realism (such as in shan shui style), beginning with the medieval Song Dynasty there were many Chinese painters then and afterwards who depicted scenes of nature that were vividly real. Later Ming Dynasty artists would take after this Song Dynasty emphasis for intricate detail and realism on objects in nature, especially in depictions of animals (such as ducks, swans, sparrows, tigers, etc.) amongst patches of brightly-colored flowers and thickets of brush and wood (a good example would be the anonymous Ming Dynasty painting Birds and Plum Blossoms , housed in the Freer Gallery of the Smithsonian Museum in Washington, D.C.). There were many renowned Ming Dynasty artists; Qiu Ying is an excellent example of a paramount Ming era painter (famous even in his own day), utilizing in his artwork domestic scenes, bustling palatial scenes, and nature scenes of river valleys and steeped mountains shrouded in mist and swirling clouds. During the Ming Dynasty there were also different and rivaling schools of art associated with painting, such as the Wu School and the Zhe School.

Classical Chinese painting continued on into the early modern Qing Dynasty, with highly realistic portrait paintings like seen in the late Ming Dynasty of the early 17th century. The portraits of Kangxi Emperor, Yongzheng Emperor, and Qianlong Emperor are excellent examples of realistic Chinese portrait painting. During the Qianlong reign period and the continuing 19th century, European Baroque styles of painting had noticeable influence on Chinese portrait paintings, especially with painted visual effects of lighting and shading. Likewise, East Asian paintings and other works of art (such as porcelain and lacquerware) were highly prized in Europe since initial contact in the 16th century.

Muromachi period, Shingei, (14311485), Viewing a Waterfall, Nezu Museum, Tokyo.

Japanese painting

Main article: Japanese painting

Japanese painting () is one of the oldest and most highly refined of the Japanese arts, encompassing a wide variety on genre and styles. As with the history of Japanese arts in general, the history Japanese painting is a long history of synthesis and competition between native Japanese aesthetics and adaptation of imported ideas. Ukiyo-e, "pictures of the floating world", is a genre of Japanese woodblock prints (or woodcuts) and paintings produced between the 17th and the 20th centuries, featuring motifs of landscapes, the theatre and pleasure quarters. It is the main artistic genre of woodblock printing in Japan. Japanese printmaking especially from the Edo period exerted enormous influence on Western painting in France during the 19th century.

South Asian painting

A group of women from South India, Hindupur, c. 1540.

Krishna embraces Gops, Gt-Govinda-manuscript, 1760-1765.

Floating Figures Dancing, a mural of c. 850.

Wild Pig Hunt, c. 1540.

Chand Bibi Hawking, Deccan style, 18th century

A Lady Listening to Music, c. 1750.

Rasamajar manuscript of the Bhnudatta (erotic treatise), 1720.

Mural fragment of a lady with a parasol, c. 700.

Bahsoli painting of Radha and Krishna in Discussion, c. 1730.

Bahsoli painting of Maharaja Sital Dev of Mankot in Devotion, c. 1690.

Portrait of Ibrahim Adil Shah II (1580-1626) of Bijapur, 1615.

The Throne of the Wealth, Nujm-al-' Ulm-manuscript, 1570.

Elephant and cub out of the stable of the Moghul ruler, 17th century.

Mihrdukht Shoots an Arrow Through a Ring, 1564-1579.

Portrait of the Govardhn Chand, Punjab style, c. 1750.

Ravana kills Jathayu; the captive Sita despairs.

Akbar and Tansen Visit Haridas in Vrindavan, Rajasthan style, c. 1750.

A man with children, Punjab style, 1760.

Rdh arrests Krishna, Punjab style, 1770.

Rama and Sita in the Forest, Punjab style, 1780.

Indian painting

Main article: Indian painting

Indian paintings historically revolved around the religious deities and kings. Indian art is a collective term for several different schools of art that existed in the Indian subcontinent. The paintings varied from large frescoes of Ellora to the intricate Mughal miniature paintings to the metal embellished works from the Tanjore school. The paintings from the Gandhar-Taxila are influenced by the Persian works in the west. The eastern style of painting was mostly developed around the Nalanda school of art. The works are mostly inspired by various scenes from Indian mythology.

History

The earliest Indian paintings were the rock paintings of prehistoric times, the petroglyphs as found in places like the Rock Shelters of Bhimbetka, and some of them are older than 5500 BC. Such works continued and after several millennia, in the 7th century, carved pillars of Ajanta, Maharashtra state present a fine example of Indian paintings, and the colors, mostly various shades of red and orange, were derived from minerals.

Bhimbetka rock painting

Ajanta Caves in Maharashtra, India are rock-cut cave monuments dating back to the second century BCE and containing paintings and sculpture considered to be masterpieces of both Buddhist religious art and universal pictorial art.

A fresco from Cave 1 of Ajanta.

Madhubani painting

Madhubani painting is a style of Indian painting, practiced in the Mithila region of Bihar state, India. The origins of Madhubani painting are shrouded in antiquity.

Mother Goddess A miniature painting of the Pahari style, dating to the eighteenth century. Pahari and Rajput miniatures share many common features.

Rajput painting

Rajput painting, a style of Indian painting, evolved and flourished, during the 18th century, in the royal courts of Rajputana, India. Each Rajput kingdom evolved a distinct style, but with certain common features. Rajput paintings depict a number of themes, events of epics like the Ramayana and the Mahabharata, Krishna's life, beautiful landscapes, and humans. Miniatures were the preferred medium of Rajput painting, but several manuscripts also contain Rajput paintings, and paintings were even done on the walls of palaces, inner chambers of the forts, havelies, particularly, the havelis of Shekhawait.

The colors extracted from certain minerals, plant sources, conch shells, and were even derived by processing precious stones, gold and silver were used. The preparation of desired colors was a lengthy process, sometimes taking weeks. Brushes used were very fine.

Mughal painting

Mughal painting is a particular style of Indian painting, generally confined to illustrations on the book and done in miniatures, and which emerged, developed and took shape during the period of the Mughal Empire 16th -19th centuries).

Tanjore painting

Tanjore painting is an important form of classical South Indian painting native to the town of Tanjore in Tamil Nadu. The art form dates back to the early 9th century, a period dominated by the Chola rulers, who encouraged art and literature. These paintings are known for their elegance, rich colors, and attention to detail. The themes for most of these paintings are Hindu Gods and Goddesses and scenes from Hindu mythology. In modern times, these paintings have become a much sought after souvenir during festive occasions in South India.

The process of making a Tanjore painting involves many stages. The first stage involves the making of the preliminary sketch of the image on the base. The base consists of a cloth pasted over a wooden base. Then chalk powder or zinc oxide is mixed with water-soluble adhesive and applied on the base. To make the base smoother, a mild abrasive is sometimes used. After the drawing is made, decoration of the jewellery and the apparels in the image is done with semi-precious stones. Laces or threads are also used to decorate the jewellery. On top of this, the gold foils are pasted. Finally, dyes are used to add colors to the figures in the paintings.

The Madras School

During British rule in India, the crown found that Madras had some of the most talented and intellectual artistic minds in the world. As the British had also established a huge settlement in and around Madras, Georgetown was chosen to establish an institute that would cater to the artistic expectations of the royals in London. This has come to be known as the Madras School. At first traditional artists were employed to produce exquisite varieties of furniture, metal work, and curios and their work was sent to the royal palaces of the Queen.

Unlike the Bengal School where 'copying' is the norm of teaching, the Madras School flourishes on 'creating' new styles, arguments and trends.

The Bengal School

Abanindranath Tagore, Bharat Mata

The Bengal School of Art was an influential style of art that flourished in India during the British Raj in the early 20th century. It was associated with Indian nationalism, but was also promoted and supported by many British arts administrators.

The Bengal School arose as an avant garde and nationalist movement reacting against the academic art styles previously promoted in India, both by Indian artists such as Ravi Varma and in British art schools. Following the widespread influence of Indian spiritual ideas in the West, the British art teacher Ernest Binfield Havel attempted to reform the teaching methods at the Calcutta School of Art by encouraging students to imitate Mughal miniatures. This caused immense controversy, leading to a strike by students and complaints from the local press, including from nationalists who considered it to be a retrogressive move. Havel was supported by the artist Abanindranath Tagore, a nephew of the poet Rabindranath Tagore. Tagore painted a number of works influenced by Mughal art, a style that he and Havel believed to be expressive of India's distinct spiritual qualities, as opposed to the "materialism" of the West. Tagore's best-known painting, Bharat Mata (Mother India), depicted a young woman, portrayed with four arms in the manner of Hindu deities, holding objects symbolic of India's national aspirations. Tagore later attempted to develop links with Japanese artists as part of an aspiration to construct a pan-Asianist model of art.

The Bengal School's influence in India declined with the spread of modernist ideas in the 1920s. In the post-independence period, Indian artists showed more adaptability as they borrowed freely from european styles and amalgamated them freely with the Indian motifs to new forms of art. While artists like Francis Newton Souza and Tyeb Mehta were more western in their approach, there were others like Ganesh Pyne and Maqbool Fida Husain who developed thoroughly indigenous styles of work. Today after the process of liberalization of market in India, the artists are experiencing more exposure to the international art-scene which is helping them in emerging with newer forms of art which were hitherto not seen in India. Jitish Kallat had shot to fame in the late 90s with his paintings which were both modern and beyond the scope of generic definition. However while artists in India in the new century are trying out new styles, themes and metaphors, it would not have been possible to get such quick recognition without the aid of the business houses which are now entering the art field like they had never before.

Western painting

See also: Western painting and Ancient art

Egypt, Greece and Rome

Ancient Egypt, a civilization with very strong traditions of architecture and sculpture (both originally painted in bright colours) also had many mural paintings in temples and buildings, and painted illustrations on papyrus manuscripts. Egyptian wall painting and decorative painting is often graphic, sometimes more symbolic than realistic. Egyptian painting depicts figures in bold outline and flat silhouette, in which symmetry is a constant characteristic. Egyptian painting has close connection with its written language - called Egyptian hieroglyphs. Painted symbols are found amongst the first forms of written language. The Egyptians also painted on linen, remnants of which survive today. Ancient Egyptian paintings survived due to the extremely dry climate. The ancient Egyptians created paintings to make the afterlife of the deceased a pleasant place. The themes included journey through the afterworld or their protective deities introducing the deceased to the gods of the underworld. Some examples of such paintings are paintings of the gods and goddesses Ra, Horus, Anubis, Nut, Osiris and Isis. Some tomb paintings show activities that the deceased were involved in when they were alive and wished to carry on doing for eternity. In the New Kingdom and later, the Book of the Dead was buried with the entombed person. It was considered important for an introduction to the afterlife.

Ancient Egypt

Ancient Egypt,The Goddess Isis, wall painting, ca.1360 BC

Ancient Egypt, Queen Nefertari

Ancient Egypt, papyrus

Ancient Egypt

Ancient Egypt

Pitsa panels, one of the few surviving panel paintings from Archaic Greece, ca. 540-530 BC

Symposium scene in the Tomb of the Diver at Paestum, circa 480 BC Greek art

Knossos

Roman art, Pompeii

Roman art

Roman art

Roman art

Roman art

Roman art

Roman art

To the north of Egypt was the Minoan civilization on the island of Crete. The wall paintings found in the palace of Knossos are similar to that of the Egyptians but much more free in style. Around 1100 B.C., tribes from the north of Greece conquered Greece and the Greek art took a new direction.

Ancient Greece had great painters, great sculptors (though both endeavours were regarded as mere manual labour at the time), and great architects. The Parthenon is an example of their architecture that has lasted to modern days. Greek marble sculpture is often described as the highest form of Classical art. Painting on pottery of Ancient Greece and ceramics gives a particularly informative glimpse into the way society in Ancient Greece functioned. Black-figure vase painting and Red-figure vase painting gives many surviving examples of what Greek painting was. Some famous Greek painters on wooden panels who are mentioned in texts are Apelles, Zeuxis and Parrhasius, however no examples of Ancient Greek panel painting survive, only written descriptions by their contemporaries or later Romans. Zeuxis lived in 5-6 BC and was said to be the first to use sfumato. According to Pliny the Elder, the realism of his paintings was such that birds tried to eat the painted grapes. Apelles is described as the greatest painter of Antiquity for perfect technique in drawing, brilliant color and modeling.

Roman art was influenced by Greece and can in part be taken as a descendant of ancient Greek painting. However, Roman painting does have important unique characteristics. The only surviving Roman paintings are wall paintings, many from villas in Campania, in Southern Italy. Such painting can be grouped into 4 main "styles" or periods and may contain the first examples of trompe-l'il, pseudo-perspective, and pure landscape. Almost the only painted portraits surviving from the Ancient world are a large number of coffin-portraits of bust form found in the Late Antique cemetery of Al-Fayum. Although these were neither of the best period nor the highest quality, they are impressive in themselves, and give an idea of the quality that the finest ancient work must have had. A very small number of miniatures from Late Antique illustrated books also survive, and a rather larger number of copies of them from the Early Medieval period.

Middle Ages

Main articles: Medieval art, Insular art, Carolingian art, Anglo-Saxon art, Romanesque art, and Gothic art

Cotton Genesis a miniature of Abraham meeting Angels

Byzantine art

Byzantine art

Byzantine art, Mosaic

Limbourg Brothers

Limbourg Brothers

Book of Kells

Book of Kells

Book of Hours

Evangelist portrait

Carolingian

Carolingian Saint Mark

Yaroslavl Gospels c. 1220s

Giottino

Vitale da Bologna

Simone Martini

Cimabue

Giotto

Giotto

Andrei Rublev

Andrei Rublev, Ascension, 1408

Ambrogio Lorenzetti

Pietro Lorenzetti

Duccio

The rise of Christianity imparted a different spirit and aim to painting styles. Byzantine art, once its style was established by the 6th century, placed great emphasis on retaining traditional iconography and style, and has changed relatively little through the thousand years of the Byzantine Empire and the continuing traditions of Greek and Russian Othodox icon-painting. Byzantine painting has a particularly hieratic feeling and icons were and still are seen as a reflection of the divine. There were also many wall-paintings in fresco, but fewer of these have survived than Byzantine mosaics. In general Byzantium art borders on abstraction, in its flatness and highly stylised depictions of figures and landscape. However there are periods, especially in the so-called Macedonian art of around the 10th century, when Byzantine art became more flexible in approach.

Book of Hours

In post-Antique Catholic Europe the first distinctive artistic style to emerge that included painting was the Insular art of the British Isles, where the only surviving examples (and quite likely the only medium in which painting was used) are miniatures in Illuminated manuscripts such as the Book of Kells. These are most famous for their abstract decoration, although figures, and sometimes scenes, were also depicted, especially in Evangelist portraits. Carolingian and Ottonian art also survives mostly in manuscripts, although some wall-painting remain, and more are documented. The art of this period combines Insular and "barbarian" influences with a strong Byzantine influence and an aspiration to recover classical monumentality and poise.

Walls of Romanesque and Gothic churches were decorated with frescoes as well as sculpture and many of the few remaining murals have great intensity, and combine the decorative energy of Insular art with a new monumentality in the treatment of figures. Far more miniatures in Illuminated manuscripts survive from the period, showing the same characteristics, which continue into the Gothic period.

Panel painting becomes more common during the Romanesque period, under the heavy influence of Byzantine icons. Towards the middle of the 13th century, Medieval art and Gothic painting became more realistic, with the beginnings of interest in the depiction of volume and perspective in Italy with Cimabue and then his pupil Giotto. From Giotto on, the treatment of composition by the best painters also became much more free and innovative. They are considered to be the two great medieval masters of painting in western culture. Cimabue, within the Byzantine tradition, used a more realistic and dramatic approach to his art. His pupil, Giotto, took these innovations to a higher level which in turn set the foundations for the western painting tradition. Both artists were pioneers in the move towards naturalism.

Churches were built with more and more windows and the use of colorful stained glass become a staple in decoration. One of the most famous examples of this is found in the cathedral of Notre Dame de Paris. By the 14th century Western societies were both richer and more cultivated and painters found new patrons in the nobility and even the bourgeoisie. Illuminated manuscripts took on a new character and slim, fashionably dressed court women were shown in their landscapes. This style soon became known as International style and tempera panel paintings and altarpieces gained importance.

Renaissance and Mannerism

Main articles: Italian Renaissance painting, Mannerism, and Northern Mannerism

Fra Angelico

Filippo Lippi

Andrea Mantegna

Masaccio The Expulsion Of Adam and Eve from Eden, before and after restoration

Paolo Uccello

Leonardo da Vinci

Raphael

Michelangelo

Albrecht Drer

Giovanni Bellini

Titian

Leonardo da Vinci

Piero della Francesca

Giorgione

Jacopo Tintoretto

Sandro Botticelli

Robert Campin

Rogier van der Weyden

Jan van Eyck

Jan van Eyck

Hieronymous Bosch

Pieter Bruegel

Hans Holbein the Younger

El Greco

The Renaissance is said by many to be the golden age of painting. Roughly spanning the 14th through the mid 17th century. In Italy artists like Paolo Uccello, Fra Angelico, Masaccio, Piero della Francesca, Andrea Mantegna, Filippo Lippi, Giorgione, Tintoretto, Sandro Botticelli, Leonardo da Vinci, Michelangelo Buonarroti, Raphael, Giovanni Bellini, and Titian took painting to a higher level through the use of perspective, the study of human anatomy and proportion, and through their development of an unprecedented refinement in drawing and painting techniques.

Flemish, Dutch and German painters of the Renaissance such as Hans Holbein the Younger, Albrecht Drer, Lucas Cranach, Matthias Grnewald, Hieronymous Bosch, and Pieter Brueghel represent a different approach from their Italian colleagues, one that is more realistic and less idealized. Genre painting became a popular idiom amongst such Northern painters as Pieter Brueghel. A new verisimilitude in depicting reality became possible with the adoption of oil painting, whose invention was traditionally, but erroneously, credited to Jan Van Eyck (an important transitional figure who bridges painting in the Middle Ages with painting of the early Renaissance). Unlike the Italians whose work drew heavily from the art of ancient Greece and Rome, the northerners retained a stylistic residue of the sculpture and illuminated manuscripts of the Middle Ages. These tendencies are also see in the art of Tudor England, which was heavily influenced by Protestant refugees from the Low Countries.

Renaissance painting reflects the revolution of ideas and science (astronomy, geography) that occur in this period, the Reformation, and the invention of the printing press. Drer, considered one of the greatest of printmakers, states that painters are not mere artisans but thinkers as well. With the development of easel painting in the Renaissance, painting gained independence from architecture. Following centuries dominated by religious imagery, secular subject matter slowly returned to Western painting. Artists included visions of the world around them, or the products of their own imaginations in their paintings. Those who could afford the expense could become patrons and commission portraits of themselves or their family.

In the fifteenth and sixteenth centuries, panel paintings which could be hung on walls and moved around at will, became increasingly popular for both churches and private houses, rather than fresco wall-paintings or paintings incorporated into on permanent structures, such as altarpieces. The High Renaissance gave rise to a stylized art known as Mannerism. In place of the balanced compositions and rational approach to perspective that characterized art at the dawn of the sixteenth century, the Mannerists sought instability, artifice, and doubt. The unperturbed faces and gestures of Piero della Francesca and the calm Virgins of Raphael are replaced by the troubled expressions of Pontormo and the emotional intensity of El Greco. Some decades later Northern Mannerism dominated Netherlandish and German art until the arrival of the Baroque.

Baroque and Rococo

Main articles: Baroque, Dutch Golden Age painting, Flemish Baroque painting, Rococo, and Quadratura

Caravaggio

Artemesia Gentileschi

Frans Hals

Peter Paul Rubens

Jan Vermeer

Rembrandt van Rijn

Diego Velazquez

Nicolas Poussin

Jos de Ribera

Salvatore Rosa

Claude Lorrain

Antony Van Dyck

Giovanni Battista Tiepolo

Antoine Watteau

Jean-Honor Fragonard, The Swing, ca. 1767

Franois Boucher

lisabeth Vige-Lebrun

Maurice Quentin de La Tour

Thomas Gainsborough

Joshua Reynolds

Jean-Baptiste-Simon Chardin

William Hogarth

Francis Hayman

Angelica Kauffman

Baroque painting is associated with the Baroque cultural movement, a movement often identified with Absolutism and the Counter Reformation or Catholic Revival ; the existence of important Baroque painting in non-absolutist and Protestant states also, however, underscores its popularity, as the style spread throughout Western Europe.

Baroque painting is characterized by great drama, rich, deep color, and intense light and dark shadows. Baroque art was meant to evoke emotion and passion instead of the calm rationality that had been prized during the Renaissance. During the period beginning around 1600 and continuing throughout the 17th century, painting is characterized as Baroque. Among the greatest painters of the Baroque are Caravaggio, Rembrandt, Frans Hals, Rubens, Velzquez, Poussin, and Jan Vermeer. Caravaggio is an heir of the humanist painting of the High Renaissance. His realistic approach to the human figure, painted directly from life and dramatically spotlit against a dark background, shocked his contemporaries and opened a new chapter in the history of painting. Baroque painting often dramatizes scenes using light effects; this can be seen in works by Rembrandt, Vermeer, Le Nain and La Tour.

During the 18th century, Rococo followed as a lighter extension of Baroque, often frivolous and erotic. Rococo developed first in the decorative arts and interior design in France. Louis XV's succession brought a change in the court artists and general artistic fashion. The 1730s represented the height of Rococo development in France exemplified by the works of Antoine Watteau and Franois Boucher. Rococo still maintained the Baroque taste for complex forms and intricate patterns, but by this point, it had begun to integrate a variety of diverse characteristics, including a taste for Oriental designs and asymmetric compositions.

The Rococo style spread with French artists and engraved publications. It was readily received in the Catholic parts of Germany, Bohemia, and Austria, where it was merged with the lively German Baroque traditions. German Rococo was applied with enthusiasm to churches and palaces, particularly in the south, while Frederician Rococo developed in the Kingdom of Prussia.

The French masters Watteau, Boucher and Fragonard represent the style, as do Giovanni Battista Tiepolo and Jean-Baptiste-Simon Chardin who was considered by some as the best French painter of the 18th century - the Anti-Rococo. Portraiture was an important component of painting in all countries, but especially in England, where the leaders were William Hogarth, in a blunt realist style, and Francis Hayman, Angelica Kauffman (who was Swiss), Thomas Gainsborough and Joshua Reynolds in more flattering styles influenced by Antony Van Dyck. While in France during the Rococo era Jean-Baptiste Greuze (the favorite painter of Denis Diderot), Maurice Quentin de La Tour, and lisabeth Vige-Lebrun were highly accomplished Portrait painters and History painters.

William Hogarth helped develop a theoretical foundation for Rococo beauty. Though not intentionally referencing the movement, he argued in his Analysis of Beauty (1753) that the undulating lines and S-curves prominent in Rococo were the basis for grace and beauty in art or nature (unlike the straight line or the circle in Classicism). The beginning of the end for Rococo came in the early 1760s as figures like Voltaire and Jacques-Franois Blondel began to voice their criticism of the superficiality and degeneracy of the art. Blondel decried the "ridiculous jumble of shells, dragons, reeds, palm-trees and plants" in contemporary interiors . By 1785, Rococo had passed out of fashion in France, replaced by the order and seriousness of Neoclassical artists like Jacques Louis David.

19th century: Neo-classicism, History painting, Romanticism, Impressionism, Post Impressionism, Symbolism

Main articles: Neoclassicism, History painting, Romanticism, Impressionism, Post Impressionism, and Symbolism (arts)

Jacques-Louis David 1787

John Singleton Copley, 1778

Antoine-Jean Gros, 1804

Jean Auguste Dominique Ingres 1862

John Constable 1802

Francisco de Goya 1814

Thodore Gricault 1819

Caspar David Friedrich c.1822

Eugne Delacroix, 1830

J. M. W. Turner 1838

Gustave Courbet 1849-1850

Camille Corot c.1867

Albert Bierstadt 1886

Claude Monet 1872

Pierre-Auguste Renoir 1876

Edgar Degas 1876

douard Manet 1882

Vincent van Gogh 1888

Paul Gauguin 1897-1898

Georges Seurat 1884-1886

Thomas Eakins, 1884-1885

Albert Pinkham Ryder, 1890

Winslow Homer 1899

Paul Czanne 1906

After Rococo there arose in the late 18th century, in architecture, and then in painting severe neo-classicism, best represented by such artists as David and his heir Ingres. Ingres' work already contains much of the sensuality, but none of the spontaneity, that was to characterize Romanticism. This movement turned its attention toward landscape and nature as well as the human figure and the supremacy of natural order above mankind's will. There is a pantheist philosophy (see Spinoza and Hegel) within this conception that opposes Enlightenment ideals by seeing mankind's destiny in a more tragic or pessimistic light. The idea that human beings are not above the forces of Nature is in contradiction to Ancient Greek and Renaissance ideals where mankind was above all things and owned his fate. This thinking led romantic artists to depict the sublime, ruined churches, shipwrecks, massacres and madness.

By the mid-19th century painters became liberated from the demands of their patronage to only depict scenes from religion, mythology, portraiture or history. The idea "art for art's sake" began to find expression in the work of painters like Francisco de Goya, John Constable, and J.M.W. Turner. Romantic painters turned landscape painting into a major genre, considered until then as a minor genre or as a decorative background for figure compositions. Some of the major painters of this period are Eugne Delacroix, Thodore Gricault, J. M. W. Turner, Caspar David Friedrich and John Constable. Francisco de Goya's late work demonstrates the Romantic interest in the irrational, while the work of Arnold Bcklin evokes mystery and the paintings of Aesthetic movement artist James McNeill Whistler evoke both sophistication and decadence. In the United States the Romantic tradition of landscape painting was known as the Hudson River School: exponents include Thomas Cole, Frederic Edwin Church, Albert Bierstadt, Thomas Moran, and John Frederick Kensett. Luminism was a movement in American landscape painting related to the Hudson River School.

The leading Barbizon School painter Camille Corot painted in both a romantic and a realistic vein; his work prefigures Impressionism, as does the paintings of Eugne Boudin who was one of the first French landscape painters to paint outdoors. Boudin was also an important influence on the young Claude Monet, whom in 1857 he introduced to Plein air painting. A major force in the turn towards Realism at mid-century was Gustave Courbet. In the latter third of the century Impressionists like douard Manet, Claude Monet, Pierre-Auguste Renoir, Camille Pissarro, Alfred Sisley, Berthe Morisot, Mary Cassatt, and Edgar Degas worked in a more direct approach than had previously been exhibited publicly. They eschewed allegory and narrative in favor of individualized responses to the modern world, sometimes painted with little or no preparatory study, relying on deftness of drawing and a highly chromatic pallette. Manet, Degas, Renoir, Morisot, and Cassatt concentrated primarily on the human subject. Both Manet and Degas reinterpreted classical figurative canons within contemporary situations; in Manet's case the re-imaginings met with hostile public reception. Renoir, Morisot, and Cassatt turned to domestic life for inspiration, with Renoir focusing on the female nude. Monet, Pissarro, and Sisley used the landscape as their primary motif, the transience of light and weather playing a major role in their work. While Sisley most closely adhered to the original principals of the Impressionist perception of the landscape, Monet sought challenges in increasingly chromatic and changeable conditions, culminating in series of monumental works, and

Edvard Munch, 1893, early example of Expressionism

Pissarro adopted some of the experiments of Post-Impressionism. Slightly younger Post-Impressionists like Vincent van Gogh, Paul Gauguin, and Georges Seurat, along with Paul Czanne led art to the edge of modernism; for Gauguin Impressionism gave way to a personal symbolism; Seurat transformed Impressionism's broken color into a scientific optical study, structured on frieze-like compositions; Van Gogh's turbulent method of paint application, coupled with a sonorous use of color, predicted Expressionism and Fauvism, and Czanne, desiring to unite classical composition with a revolutionary abstraction of natural forms, would come to be seen as a precursor of 20th century art. The spell of Impressionism was felt throughout the world, including in the United States, where it became integral to the painting of American Impressionists such as Childe Hassam, John Twachtman, and Theodore Robinson. It also exerted influence on painters who were not primarily Impressionistic in theory, like the portrait and landscape painter John Singer Sargent. At the same time in America at the turn of the century there existed a native and nearly insular realism, as richly embodied in the figurative work of Thomas Eakins, the Ashcan School, and the landscapes and seascapes of Winslow Homer, all of whose paintings were deeply invested in the solidity of natural forms. The visionary landscape, a motive largely dependent on the ambiguity of the nocturne, found its advocates in Albert Pinkham Ryder and Ralph Albert Blakelock.

In the late 19th century there also were several, rather dissimilar, groups of Symbolist painters whose works resonated with younger artists of the 20th century, especially with the Fauvists and the Surrealists. Among them were Gustave Moreau, Odilon Redon, Pierre Puvis de Chavannes, Henri Fantin-Latour, Arnold Bcklin, Edvard Munch, Flicien Rops, and Jan Toorop, and Gustave Klimt amongst others including the Russian Symbolists like Mikhail Vrubel.

Symbolist painters mined mythology and dream imagery for a visual language of the soul, seeking evocative paintings that brought to mind a static world of silence. The symbols used in Symbolism are not the familiar emblems of mainstream iconography but intensely personal, private, obscure and ambiguous references. More a philosophy than an actual style of art, the Symbolist painters influenced the contemporary Art Nouveau movement and Les Nabis. In their exploration of dreamlike subjects, symbolist painters are found across centuries and cultures, as they are still today; Bernard Delvaille has described Ren Magritte's surrealism as "Symbolism plus Freud".

20th century Modern and Contemporary

Main articles: Modern Art, Modernism, and Contemporary art

The heritage of painters like Van Gogh, Czanne, Gauguin, and Seurat was essential for the development of modern art. At the beginning of the 20th century Henri Matisse and several other young artists revolutionized the Paris art world with "wild", multi-colored, expressive, landscapes and figure paintings that the critics called Fauvism. Pablo Picasso made his first cubist paintings based on Czanne's idea that all depiction of nature can be reduced to three solids: cube, sphere and cone.

Pioneers of the 20th century

Henri Matisse 1905, Fauvism

Pablo Picasso 1907, early Cubism

Georges Braque 1910, Analytic Cubism

Henri Rousseau 1910 Primitive Surrealism

The heritage of painters like Van Gogh, Czanne, Gauguin, and Seurat was essential for the development of modern art. At the beginning of the 20th century Henri Matisse and several other young artists including the pre-cubist Georges Braque, Andr Derain, Raoul Dufy and Maurice de Vlaminck revolutionized the Paris art world with "wild", multi-colored, expressive, landscapes and figure paintings that the critics called Fauvism - (as seen in the gallery above). Henri Matisse's second version of The Dance signifies a key point in his career and in the development of modern painting. It reflects Matisse's incipient fascination with primitive art: the intense warm colors against the cool blue-green background and the rhythmical succession of dancing nudes convey the feelings of emotional liberation and hedonism. Pablo Picasso made his first cubist paintings based on Czanne's idea that all depiction of nature can be reduced to three solids: cube, sphere and cone. With the painting Les Demoiselles d'Avignon 1907, (see gallery) Picasso dramatically created a new and radical picture depicting a raw and primitive brothel scene with five prostitutes, violently painted women, reminiscent of African tribal masks and his own new Cubist inventions. Analytic cubism (see gallery) was jointly developed by Pablo Picasso and Georges Braque, exemplified by Violin and Candlestick, Paris, (seen above) from about 1908 through 1912. Analytic cubism, the first clear manifestation of cubism, was followed by Synthetic cubism, practised by Braque, Picasso, Fernand Lger, Juan Gris, Albert Gleizes, Marcel Duchamp and countless other artists into the 1920s. Synthetic cubism is characterized by the introduction of different textures, surfaces, collage elements, papier coll and a large variety of merged subject matter.

Henri Matisse 1909, late Fauvism

Giorgio de Chirico 1914, pre-Surrealism

Les Fauves (French for The Wild Beasts) were early 20th century painters, experimenting with freedom of expression through color. The name was given, humorously and not as a compliment, to the group by art critic Louis Vauxcelles. Fauvism was a short-lived and loose grouping of early 20th century artists whose works emphasized painterly qualities, and the imaginative use of deep color over the representational values. Fauvists made the subject of the painting easy to read, exaggerated perspectives and an interesting prescient prediction of the Fauves was expressed in 1888 by Paul Gauguin to Paul Srusier,

"How do you see these trees? They are yellow. So, put in yellow; this shadow, rather blue, paint it with pure ultramarine; these red leaves? Put in vermilion."

The leaders of the movement were Henri Matisse and Andr Derain friendly rivals of a sort, each with his own followers. Ultimately Matisse became the yang to Picasso's yin in the 20th century. Fauvist painters included Albert Marquet, Charles Camoin, Maurice de Vlaminck, Raoul Dufy, Othon Friesz, the Dutch painter Kees van Dongen, and Picasso's partner in Cubism, Georges Braque amongst others.

Fauvism, as a movement, had no concrete theories, and was short lived, beginning in 1905 and ending in 1907, they only had three exhibitions. Matisse was seen as the leader of the movement, due to his seniority in age and prior self-establishment in the academic art world. His 1905 portrait of Mme. Matisse The Green Line, (above), caused a sensation in Paris when it was first exhibited. He said he wanted to create art to delight; art as a decoration was his purpose and it can be said that his use of bright colors tries to maintain serenity of composition. In 1906 at the suggestion of his dealer Ambroise Vollard, Andr Derain went to London and produced a series of paintings like Charing Cross Bridge, London (above) in the Fauvist style, paraphrasing the famous series by the Impressionist painter Claude Monet. Masters like Henri Matisse and Pierre Bonnard continued developing their narrative styles independent of any movement throughout the 20th century.

Pierre Bonnard, 1913, European modernist Narrative painting

By 1907 Fauvism no longer was a shocking new movement, soon it was replaced by Cubism on the critics radar screen as the latest new development in Contemporary Art of the time. In 1907 Appolinaire, commenting about Matisse in an article published in La Falange, said, "We are not here in the presence of an extravagant or an extremist undertaking: Matisse's art is eminently reasonable." Analytic cubism (see gallery) was jointly developed by Pablo Picasso and Georges Braque from about 1908 through 1912. Analytic cubism, the first clear manifestation of cubism, was followed by Synthetic cubism, practised by Braque, Picasso, Fernand Lger, Juan Gris, Albert Gleizes, Marcel Duchamp and countless other artists into the 1920s. Synthetic cubism is characterized by the introduction of different textures, surfaces, collage elements, papier coll and a large variety of merged subject matter.

During the years between 1910 and the end of World War I and after the heyday of cubism, several movements emerged in Paris. Giorgio De Chirico moved to Paris in July 1911, where he joined his brother Andrea (the poet and painter known as Alberto Savinio). Through his brother he met Pierre Laprade a member of the jury at the Salon dutomne, where he exhibited three of his dreamlike works: Enigma of the Oracle, Enigma of an Afternoon and Self-Portrait. During 1913 he exhibited his work at the Salon des Indpendants and Salon dutomne, his work was noticed by Pablo Picasso and Guillaume Apollinaire and several others. His compelling and mysterious paintings are considered instrumental to the early beginnings of Surrealism. (see gallery)

Pioneers of Modern art

Marc Chagall 1911, Expressionism and Surrealism

Franz Marc 1912, Der Blaue Reiter

Robert Delaunay, 1911, Orphism

Fernand Leger 1919, Synthetic Cubism, Tubism

In the first two decades of the 20th century and after cubism, several other important movements emerged; Futurism (Balla), Abstract art (Kandinsky), Der Blaue Reiter), Bauhaus, (Kandinsky) and (Klee), Orphism, (Robert Delaunay and Frantiek Kupka), Synchromism (Morgan Russell), De Stijl (Mondrian), Suprematism (Malevich), Constructivism (Tatlin), Dadaism (Duchamp, Picabia, Arp) and Surrealism (De Chirico, Andr Breton, Mir, Magritte, Dal, Ernst). Modern painting influenced all the visual arts, from Modernist architecture and design, to avant-garde film, theatre and modern dance and became an experimental laboratory for the expression of visual experience, from photography and concrete poetry to advertising art and fashion. Van Gogh's painting exerted great influence upon 20th century Expressionism, as can be seen in the work of the Fauves, Die Brcke (a group led by German painter Ernst Kirchner), and the Expressionism of Edvard Munch, Egon Schiele, Marc Chagall, Amedeo Modigliani, Chaim Soutine and others..

Amedeo Modigliani, Portrait of Soutine 1916, example of Expressionism

Wassily Kandinsky 1913, birth of Abstract Art

Wassily Kandinsky a Russian painter, printmaker and art theorist, one of the most famous 20th-century artists is generally considered the first important painter of modern abstract art. As an early modernist, in search of new modes of visual expression, and spiritual expression, he theorized as did contemporary occultists and theosophists, that pure visual abstraction had corollary vibrations with sound and music. They posited that pure abstraction could express pure spirituality. His earliest abstractions were generally titled as the example in the (above gallery) Composition VII, making connection to the work of the composers of music. Kandinsky included many of his theories about abstract art in his book Concerning the Spiritual in Art. Robert Delaunay was a French artist who is associated with Orphism, (reminiscent of a link between pure abstraction and cubism). His later works were more abstract, reminiscent of Paul Klee. His key contributions to abstract painting refer to his bold use of color, and a clear love of experimentation of both depth and tone. At the invitation of Wassily Kandinsky, Delaunay and his wife the artist Sonia Delaunay, joined The Blue Rider (Der Blaue Reiter), a Munich-based group of abstract artists, in 1911, and his art took a turn to the abstract. Other Major pioneers of early abstraction include Russian painter Kasimir Malevich, who after the Russian Revolution in 1917, and after pressure from the Stalinist regime in 1924 returned to painting imagery and Peasants and Workers in the field, and Swiss painter Paul Klee whose masterful color experiments made him an important pioneer of abstract painting at the Bauhaus. Still other important pioneers of abstract painting include the Swedish artist Hilma af Klint, Czech painter, Frantiek Kupka as well as American artists Stanton MacDonald-Wright and Morgan Russell who, in 1912, founded Synchromism, an art movement that closely resembles Orphism.

Edvard Munch, Death of Marat I (1907), an example of Expressionism

Gustav Klimt, Expressionism, 19071908

Expressionism and Symbolism are broad rubrics that describes several important and related movements in 20th century painting that dominated much of the avant-garde art being made in Western, Eastern and Northern Europe. Expressionism was painted largely between World War I and World War II, mostly in France, Germany, Norway, Russia, Belgium, and Austria. Expressionist artists are related to both Surrealism and Symbolism and are each uniquely and somewhat eccentrically personal. Fauvism, Die Brcke, and Der Blaue Reiter are three of the best known groups of Expressionist and Symbolist painters. Artists as interesting and diverse as Marc Chagall, whose painting I and the Village, (above) tells an autobiographical story that examines the relationship between the artist and his origins, with a lexicon of artistic Symbolism. Gustav Klimt, Egon Schiele, Edvard Munch, Emil Nolde, Chaim Soutine, James Ensor, Oskar Kokoschka, Ernst Ludwig Kirchner, Max Beckmann, Franz Marc, Kthe Schmidt Kollwitz, Georges Rouault, Amedeo Modigliani and some of the Americans abroad like Marsden Hartley, and Stuart Davis, were considered influential expressionist painters. Although Alberto Giacometti is primarily thought of as an intense Surrealist sculptor, he made intense expressionist paintings as well.

Pioneers of abstraction

Kasimir Malevich 1916, Suprematism

Theo van Doesburg 1917, De Stijl, Neo-Plasticism

Stanton MacDonald-Wright 1920, Synchromism

Piet Mondrian 1937-1942, De Stijl

Piet Mondrian's art was also related to his spiritual and philosophical studies. In 1908 he became interested in the theosophical movement launched by Helena Petrovna Blavatsky in the late 19th century. Blavatsky believed that it was possible to attain a knowledge of nature more profound than that provided by empirical means, and much of Mondrian's work for the rest of his life was inspired by his search for that spiritual knowledge.

De Stijl also known as neoplasticism, was a Dutch artistic movement founded in 1917. The term De Stijl is used to refer to a body of work from 1917 to 1931 founded in the Netherlands.

De Stijl is also the name of a journal that was published by the Dutch painter, designer, writer, and critic Theo van Doesburg propagating the group's theories. Next to van Doesburg, the group's principal members were the painters Piet Mondrian, Vilmos Huszr, and Bart van der Leck, and the architects Gerrit Rietveld, Robert van 't Hoff, and J.J.P. Oud. The artistic philosophy that formed a basis for the group's work is known as neoplasticism the new pla...

Pigment dispersion syndrome

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Pigment dispersion syndrome (PDS) is an affliction of the eye that, if left untreated, can lead to a form of glaucoma known as pigmentary glaucoma. It takes place when pigment cells slough off from the back of the iris and float around in the aqueous humor. This is not what causes problems; however, if the pigment flakes clog the trabecular meshwork, preventing the liquids in the eye from draining, pressure can build up inside the eye. This pressure can cause permanent damage to the optic nerve.

This condition is rare, but occurs most often in Caucasians, particularly men, and the age of onset is relatively low: mid 20s to 40s. For some reason, after 40 years of age, the syndrome lessens and stops. Most sufferers are nearsighted. bitter almond oil

There is no cure as of yet, but PDS can be managed with eye drops or treated with simple surgeries. One of the surgeries is the YAG laser procedure in which a laser is used to break up the pigment clogs, and reduce pressure. If caught early and treated, chances of glaucoma are greatly reduced. Sufferers are often advised not to engage in high-impact sports such as long-distance running or martial arts, as strong impacts can cause more pigment cells to slough off. hyaluronic acid food

External links potash alum

Global Glaucoma Institute - Mexico

NY Glaucoma Research Institute

Glaucoma Research Foundation

Handbook of Ocular Disease Management from Review of Optometry

Krukenberg's Spindle is a website designed specifically for people that have been diagnosed with Krukenberg's Spindles and/or Pigment Dispersion Syndrome

The New York Eye and Ear Infirmary

International Glaucoma Association

This eye article is a stub. You can help Wikipedia by expanding it.

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Cervical cancer

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Classification

The naming and classification of cervical carcinoma percursor lesions has changed many times over the 20th century. The World Health Organization classification system was descriptive of the lesions, naming them mild, moderate or severe dysplasia or carcinoma in situ (CIS). The term, Cervical Intraepithelial Neoplasia (CIN) was developed to place emphasis on the spectrum of abnormality in these lesions, and to help standardise treatment. It classifies mild dysplasia as CIN1, moderate dysplasia as CIN2, and severe dysplasia and CIS as CIN3. The most recent classification is the Bethesda System, which divides all cervical epithelial presursor lesions into 2 groups: Low-grade Squamous Intraepithelial Lesion (LSIL) and High-grade Squamous Intraepithelial Lesion (HSIL). LSIL corresponds to CIN1, and HSIL includes CIN2 and CIN3. More recently, CIN2 and CIN3 have been combined into CIN2/3.

Signs and symptoms veterinary surgical instruments

The early stages of cervical cancer may be completely asymptomatic. Vaginal bleeding, contact bleeding or (rarely) a vaginal mass may indicate the presence of malignancy. Also, moderate pain during sexual intercourse and vaginal discharge are symptoms of cervical cancer. In advanced disease, metastases may be present in the abdomen, lungs or elsewhere. acrylic nail drill

Symptoms of advanced cervical cancer may include: loss of appetite, weight loss, fatigue, pelvic pain, back pain, leg pain, single swollen leg, heavy bleeding from the vagina, leaking of urine or feces from the vagina, and bone fractures. dental impression trays

Causes

Human papillomavirus infection

The most important risk factor in the development of cervical cancer is infection with a high-risk strain of human papillomavirus. The virus cancer link works by triggering alterations in the cells of the cervix, which can lead to the development of cervical intraepithelial neoplasia, which can lead to cancer.

Women who have many sexual partners (or who have sex with men who had many other partners) have a greater risk.

More than 150 types of HPV are acknowledged to exist (some sources indicate more than 200 subtypes). Of these, 15 are classified as high-risk types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82), 3 as probable high-risk (26, 53, and 66), and 12 as low-risk (6, 11, 40, 42, 43, 44, 54, 61, 70, 72, 81, and CP6108), but even those may cause cancer. Types 16 and 18 are generally acknowledged to cause about 70% of cervical cancer cases. Together with type 31, they are the prime risk factors for cervical cancer.

Genital warts are caused by various strains of HPV which are usually not related to cervical cancer.

The medically accepted paradigm, officially endorsed by the American Cancer Society and other organizations, is that a patient must have been infected with HPV to develop cervical cancer, and is hence viewed as a sexually transmitted disease, but most women infected with high risk HPV will not develop cervical cancer. Use of condoms reduces, but does not always prevent transmission. Likewise, HPV can be transmitted by skin-to-skin-contact with infected areas. In males, HPV is thought to grow preferentially in the epithelium of the glans penis, and cleaning of this area may be preventative.

Cofactors

The American Cancer Society provides the following list of risk factors for cervical cancer: human papillomavirus (HPV) infection, smoking, HIV infection, chlamydia infection, dietary factors, hormonal contraception, multiple pregnancies, exposure to the hormonal drug diethylstilbestrol (DES) and a family history of cervical cancer. There is a possible genetic risk associated with HLA-B7.[citation needed]

There has not been any definitive evidence to support the claim that circumcision of the male partner reduces the risk of cervical cancer, although some researchers say there is compelling epidemiological evidence that men who have been circumcised are less likely to be infected with HPV. However, in men with low-risk sexual behaviour and monogamous female partners, circumcision makes no difference to the risk of cervical cancer.

Diagnosis

Visual inspection to detect precancer or cancer

Visual inspection of the cervix, using acetic acid or Lugol iodine to highlight precancerous lesions so they can be viewed with the aked eye, shifts the identification of precancer from the laboratory to the clinic. Such procedures eliminate the need for laboratories and transport of specimens, require very little equipment and provide women with immediate test results. A range of medical professionalsoctors, nurses, or professional midwivesan effectively perform the procedure, provided they receive adequate training and supervision. As a screening test, VIA performs equal to or better than cervical cytology in accurately identifying pre-cancerous lesions. This has been demonstrated in various studies where trained physicians and mid level providers correctly identified between 45% and 79% of women at high risk of developing cervical cancer. By comparison, the sensitivity of cytology has been shown to be between 47 and 62%.It should be noted, however, that cytology provides higher specificity than VIA. Like cytology, one of the limitations of VIA is that results are highly dependant on the accuracy of an individual interpretation. This means that initial training and on-going quality control are of paramount importance.

VIA can offer significant advantages over Pap in low-resource settings, particularly in terms of increased screening coverage, improved follow up care and overall program quality. Due to the need for fewer specialized personnel and less infrastructure, training, and equipment, with VIA public health systems can offer cervical cancer screening in more remote (and less equipped) health care settings and can achieve higher coverage. Furthermore, providers can share the results of VIA with patients immediately, making it possible to screen and treat women during the same visit. This helps ensure that follow up care can be provided on the spot and reduces the number of women who may miss out on treatment because they are not able to return to the clinic at another time. In a creen and treat project in Peru, for example, only 9% of women who screened positive failed to receive treatment in the single-visit approach, compared with 44% of women who were lost to treatment using a multi-visit model.

VIA has successfully been paired with cryotherapy, a relatively simple and inexpensive method of treating cervical lesions that can be performed by primary care physicians and mid-level providers.

Biopsy procedures

While the pap smear is an effective screening test, confirmation of the diagnosis of cervical cancer or pre-cancer requires a biopsy of the cervix. This is often done through colposcopy, a magnified visual inspection of the cervix aided by using a dilute acetic acid (e.g. vinegar) solution to highlight abnormal cells on the surface of the cervix.

Further diagnostic procedures are loop electrical excision procedure (LEEP) and conization, in which the inner lining of the cervix is removed to be examined pathologically. These are carried out if the biopsy confirms severe cervical intraepithelial neoplasia.

Pathologic types

This large squamous carcinoma (bottom of picture) has obliterated the cervix and invaded the lower uterine segment. The uterus also has a round leiomyoma up higher.

Cervical intraepithelial neoplasia, the precursor to cervical cancer, is often diagnosed on examination of cervical biopsies by a pathologist. Histologic subtypes of invasive cervical carcinoma include the following: Though squamous cell carcinoma is the cervical cancer with the most incidence, the incidence of adenocarcinoma of the cervix has been increasing in recent decades.

squamous cell carcinoma (about 80-85%[citation needed])

adenocarcinoma (about 15% of cervical cancers in the UK)

adenosquamous carcinoma

small cell carcinoma

neuroendocrine carcinoma

Non-carcinoma malignancies which can rarely occur in the cervix include

melanoma

lymphoma

Note that the FIGO stage does not incorporate lymph node involvement in contrast to the TNM staging for most other cancers.

For cases treated surgically, information obtained from the pathologist can be used in assigning a separate pathologic stage but is not to replace the original clinical stage.

For premalignant dysplastic changes, the CIN (cervical intraepithelial neoplasia) grading is used.

Staging

Cervical cancer is staged by the International Federation of Gynecology and Obstetrics (IFGO) staging system, which is based on clinical examination, rather than surgical findings. It allows only the following diagnostic tests to be used in determining the stage: palpation, inspection, colposcopy, endocervical curettage, hysteroscopy, cystoscopy, proctoscopy, intravenous urography, and X-ray examination of the lungs and skeleton, and cervical conization.

The TNM staging system for cervical cancer is analogous to the FIGO stage.

Stage 0 - full-thickness involvement of the epithelium without invasion into the stroma (carcinoma in situ)

Stage I - limited to the cervix

IA - diagnosed only by microscopy; no visible lesions

IA1 - stromal invasion less than 3 mm in depth and 7 mm or less in horizontal spread

IA2 - stromal invasion between 3 and 5 mm with horizontal spread of 7 mm or less

IB - visible lesion or a microscopic lesion with more than 5 mm of depth or horizontal spread of more than 7 mm

IB1 - visible lesion 4 cm or less in greatest dimension

IB2 - visible lesion more than 4 cm

Stage II - invades beyond cervix

IIA - without parametrial invasion, but involve upper 2/3 of vagina

IIB - with parametrial invasion

Stage III - extends to pelvic wall or lower third of the vagina

IIIA - involves lower third of vagina

IIIB - extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney

IVA - invades mucosa of bladder or rectum and/or extends beyond true pelvis

IVB - distant metastasis

Treatment

Microinvasive cancer (stage IA) is usually treated by hysterectomy (removal of the whole uterus including part of the vagina). For stage IA2, the lymph nodes are removed as well. An alternative for patients who desire to remain fertile is a local surgical procedure such as a loop electrical excision procedure (LEEP) or cone biopsy.

If a cone biopsy does not produce clear margins, one more possible treatment option for patients who want to preserve their fertility is a trachelectomy. This attempts to surgically remove the cancer while preserving the ovaries and uterus, providing for a more conservative operation than a hysterectomy. It is a viable option for those in stage I cervical cancer which has not spread; however, it is not yet considered a standard of care, as few doctors are skilled in this procedure. Even the most experienced surgeon cannot promise that a trachelectomy can be performed until after surgical microscopic examination, as the extent of the spread of cancer is unknown. If the surgeon is not able to microscopically confirm clear margins of cervical tissue once the patient is under general anesthesia in the operating room, a hysterectomy may still be needed. This can only be done during the same operation if the patient has given prior consent. Due to the possible risk of cancer spread to the lymph nodes in stage 1b cancers and some stage 1a cancers, the surgeon may also need to remove some lymph nodes from around the uterus for pathologic evaluation.

A radical trachelectomy can be performed abdominally or vaginally and there are conflicting opinions as to which is better. A radical abdominal trachelectomy with lymphadenectomy usually only requires a two to three day hospital stay, and most women recover very quickly (approximately six weeks). Complications are uncommon, although women who are able to conceive after surgery are susceptible to preterm labor and possible late miscarriage. It is generally recommended to wait at least one year before attempting to become pregnant after surgery. Recurrence in the residual cervix is very rare if the cancer has been cleared with the trachelectomy. Yet, it is recommended for patients to practice vigilant prevention and follow up care including pap screenings/colposcopy, with biopsies of the remaining lower uterine segment as needed (every 34 months for at least 5 years) to monitor for any recurrence in addition to minimizing any new exposures to HPV through safe sex practices until one is actively trying to conceive.

Early stages (IB1 and IIA less than 4 cm) can be treated with radical hysterectomy with removal of the lymph nodes or radiation therapy. Radiation therapy is given as external beam radiotherapy to the pelvis and brachytherapy (internal radiation). Patients treated with surgery who have high risk features found on pathologic examination are given radiation therapy with or without chemotherapy in order to reduce the risk of relapse.

Larger early stage tumors (IB2 and IIA more than 4 cm) may be treated with radiation therapy and cisplatin-based chemotherapy, hysterectomy (which then usually requires adjuvant radiation therapy), or cisplatin chemotherapy followed by hysterectomy.

Advanced stage tumors (IIB-IVA) are treated with radiation therapy and cisplatin-based chemotherapy.

On June 15, 2006, the US Food and Drug Administration approved the use of a combination of two chemotherapy drugs, hycamtin and cisplatin for women with late-stage (IVB) cervical cancer treatment. Combination treatment has significant risk of neutropenia, anemia, and thrombocytopenia side effects. Hycamtin is manufactured by GlaxoSmithKline.

Prevention

Awareness

According to the US National Cancer Institute's 2005 Health Information National Trends survey, only 40% of American women surveyed had heard of human papillomavirus (HPV) infection and only 20% had heard of its link to cervical cancer. In 2008 an estimated 3,870 women in the US will die of cervical cancer, and around 11,000 new cases are expected to be diagnosed.

A Fan Page was created on Facebook called Cervical Cancer Patients Unite inviting others to see some of the equipment and to learn more about what women with Cervical Cancer endure during radiation treatment. In addition, to provide a platform for those diagnosed with Cervical Cancer along with their friends, family, and associates to talk about the disease and create a virtual support group.

Screening

The widespread introduction of the Papanicolaou test, or Pap smear for cervical cancer screening has been credited with dramatically reducing the incidence and mortality of cervical cancer in developed countries. Abnormal Pap smear results may suggest the presence of cervical intraepithelial neoplasia (potentially premalignant changes in the cervix) before a cancer has developed, allowing examination and possible preventive treatment. Recommendations for how often a Pap smear should be done vary from once a year to once every five years. The ACS recommends that cervical cancer screening should begin approximately three years after the onset of vaginal intercourse and/or no later than twenty-one years of age. Guidelines vary on how long to continue screening, but well screened women who have not had abnormal smears can stop screening about age 65 (USPSTF) to 70 (ACS). If premalignant disease or cervical cancer is detected early, it can be monitored or treated relatively noninvasively, and without impairing fertility.

Until recently the Pap smear has remained the principal technology for preventing cervical cancer. However, following a rapid review of the published literature, originally commissioned by NICE , liquid based cytology has been incorporated within the UK national screening programme. Although it was probably intended to improve on the accuracy of the Pap test, its main advantage has been to reduce the number of inadequate smears from around 9% to around 1%. This reduces the need to recall women for a further smear.

Automated technologies have been developed with the aim of improving on the interpretation of smears, normally carried out by cytotechnologists. Unfortunately these on the whole have proven less useful; although the more recent reviews suggest that generally they may be no worse than human interpretation .

The HPV test is a newer technique for cervical cancer triage which detects the presence of human papillomavirus infection in the cervix. It is more sensitive than the pap smear (less likely to produce false negative results), but less specific (more likely to produce false positive results) and its role in routine screening is still evolving. Since more than 99% of invasive cervical cancers worldwide contain HPV, some researchers recommend that HPV testing be done together with routine cervical screening. But, given the prevalence of HPV (around 80% infection history among the sexually active population) others suggest that routine HPV testing would cause undue alarm to carriers.

HPV testing can reduce the incidence of grade 2 or 3 cervical intraepithelial neoplasia or cervical cancer detected by subsequent screening tests among women 3238 years old according to a randomized controlled trial. The relative risk reduction was 41.3%. For patients at similar risk to those in this study (63.0% had CIN 2-3 or cancer), this leads to an absolute risk reduction of 26%. 3.8 patients must be treated for one to benefit (number needed to treat = 3.8). Click here to adjust these results for patients at higher or lower risk of CIN 2-3.

Vaccination

Main article: HPV vaccine

Gardasil, licensed and manufactured by Merck & Co. is a vaccine against HPV types 6, 11, 16 & 18. Gardasil is up to 98% effective.. It is now on the market after receiving approval from the US Food and Drug Administration on June 8, 2006. Gardasil has also been approved in the EU.

GlaxoSmithKline has developed a vaccine called Cervarix which has been shown to be 92% effective in preventing HPV strains 16 and 18 and is effective for more than four years. Cervarix has been approved some places and is in approval process elsewhere.

Neither Merck & Co. nor GlaxoSmithKline invented the vaccine. The vaccine's key developmental steps are claimed by the National Cancer Institute in the US, the University of Rochester in New York, Georgetown University in Washington, DC, Dartmouth College in Hanover, NH, and the University of Queensland in Brisbane, Australia. Both Merck & Co. and GlaxoSmithKline have licensed patents from all of these parties.

Together, HPV types 16 and 18 currently cause about 70% of cervical cancer cases. HPV types 6 and 11 cause about 90% of genital wart cases.

HPV vaccines are targeted at girls and women of age 9 to 26 because the vaccine only works if given before infection occurs; therefore, public health workers are targeting girls before they begin having sex. The use of the vaccine in men to prevent genital warts and interrupt transmission to women or other men is initially considered only a secondary market.

The high cost of this vaccine has been a cause for concern. Several countries have or are considering programs to fund HPV vaccination.

Condoms

Condoms offer some protection against cervical cancer. Evidence on whether condoms protect against HPV infection is mixed, but they do provide protection against genital warts and the precursors to cervical cancer. They also provide protection against other STDs, such as HIV and Chlamydia, which are associated with greater risks of developing cervical cancer.

Condoms may also be useful in treating potentially precancerous changes in the cervix. Exposure to semen appears to increase the risk of precancerous changes (CIN 3), and use of condoms helps to cause these changes to regress and helps clear HPV. One study suggests that prostaglandin in semen may fuel the growth of cervical and uterine tumours and that affected women may benefit from the use of condoms.

Smoking avoidance

Main article: Smoking cessation

Carcinogens from tobacco increase the risk for many cancer types, including cervical cancer, and women who smoke have about double the chance of a non-smoker to develop cervical cancer.

Nutrition

Fruits and vegetables

Higher levels of vegetable consumption were associated with a 54% decrease risk of HPV persistence. Consumption of papaya at least once a week was inversely associated with persistent HPV infection.

Vitamin A

There is weak evidence to suggest a significant deficiency of retinol can increase chances of cervical dysplasia, independently of HPV infection. A small (n~=500) case-control study of a narrow ethnic group (native Americans in New Mexico) assessed serum micro-nutrients as risk factors for cervical dysplasia. Subjects in the lowest serum retinol quartile were at increased risk of CIN I compared with women in the highest quartile.

However, the study population had low overall serum retinol, suggesting deficiency. A study of serum retinol in a well-nourished population reveals that the bottom 20% had serum retinol close to that of the highest levels in this New Mexico sub-population.

Vitamin C

Risk of type-specific, persistent HPV infection was lower among women reporting intake values of vitamin C in the upper quartile compared with those reporting intake in the lowest quartile.

Vitamin E

HPV clearance time was significantly shorter among women with the highest compared with the lowest serum levels of tocopherols, but significant trends in these associations were limited to infections lasting </=120 days. Clearance of persistent HPV infection (lasting >120 days) was not significantly associated with circulating levels of tocopherols. Results from this investigation support an association of micronutrients with the rapid clearance of incident oncogenic HPV infection of the uterine cervix.

A statistically significantly lower level of alpha-tocopherol was observed in the blood serum of HPV-positive patients with cervical intraepithelial neoplasia. The risk of dysplasia was four times higher for an alpha-tocopherol level < 7.95 mumol/l. jojo

Folic acid

Higher folate status was inversely associated with becoming HPV test-positive. Women with higher folate status were significantly less likely to be repeatedly HPV test-positive and more likely to become test-negative. Studies have shown that lower levels of antioxidants coexisting with low levels of folic acid increases the risk of CIN development. Improving folate status in subjects at risk of getting infected or already infected with high-risk HPV may have a beneficial impact in the prevention of cervical cancer.

However, another study showed no relationship between folate status and cervical dysplasia.

Carotenoids

Higher circulating levels of carotenoids were associated with a significant decrease in the clearance time of type-specific HPV infection, particularly during the early stages of infection (</=120 days). Clearance of persistent HPV infection (lasting >120 days) was not significantly associated with circulating levels of carotenoids.

The likelihood of clearing an oncogenic HPV infection is significantly higher with increasing levels of lycopenes. A 56% reduction in HPV persistence risk was observed in women with the highest plasma [lycopene] concentrations compared with women with the lowest plasma lycopene concentrations. These data suggests that vegetable consumption and circulating lycopene may be protective against HPV persistence.

CoQ10

Women who had either CIN or cervical cancer had markedly lower levels of CoQ10 in their blood and in their cervical cells than the women who were healthy.[citation needed]

Prognosis

Prognosis depends on the stage of the cancer. With treatment, the 5-year relative survival rate for the earliest stage of invasive cervical cancer is 92%, and the overall (all stages combined) 5-year survival rate is about 72%. These statistics may be improved when applied to women newly diagnosed, bearing in mind that these outcomes may be partly based on the state of treatment five years ago when the women studied were first diagnosed.

With treatment, 80 to 90% of women with stage I cancer and 50 to 65% of those with stage II cancer are alive 5 years after diagnosis. Only 25 to 35% of women with stage III cancer and 15% or fewer of those with stage IV cancer are alive after 5 years.

According to the International Federation of Gynecology and Obstetrics, survival improves when radiotherapy is combined with cisplatin-based chemotherapy.

As the cancer metastasizes to other parts of the body, prognosis drops dramatically because treatment of local lesions is generally more effective than whole body treatments such as chemotherapy.

Interval evaluation of the patient after therapy is imperative. Recurrent cervical cancer detected at its earliest stages might be successfully treated with surgery, radiation, chemotherapy, or a combination of the three. Thirty-five percent of patients with invasive cervical cancer have persistent or recurrent disease after treatment.

Average years of potential life lost from cervical cancer are 25.3 (SEER Cancer Statistics Review 1975-2000, National Cancer Institute (NCI)). Approximately 4,600 women were projected to die in 2001 in the US of cervical cancer (DSTD), and the annual incidence was 13,000 in 2002 in the US, as calculated by SEER. Thus the ratio of deaths to incidence is approximately 35.4%.

Regular screening has meant that pre cancerous changes and early stage cervical cancers have been detected and treated early. Figures suggest that cervical screening is saving 5,000 lives each year in the UK by preventing cervical cancer. About 1,000 women per year die of cervical cancer in the UK.

Regular two-yearly Pap tests can reduce the incidence of cervical cancer by up to 90% in Australia, and save 1,200 Australian women dying from the disease each year.

Epidemiology

Age-standardized death from cervical cancer per 100,000 inhabitants in 2004.

     no data      less than 2.4      2.4-4.8      4.8-7.2      7.2-9.6      9.6-12      12-14.4      14.4-16.8      16.8-19.2      19.2-21.6      21.6-24      24-26.4      more than 26.4

Worldwide, cervical cancer is the fifth most deadly cancer in women. It affects about 16 per 100,000 women per year and kills about 9 per 100,000 per year.

In the United States, it is only the 8th most common cancer of women. In 1998, about 12,800 women were diagnosed in the US and about 4,800 died. Among gynecological cancers it ranks behind endometrial cancer and ovarian cancer. The incidence and mortality in the US are about half those for the rest of the world, which is due in part to the success of screening with the Pap smear. The incidence of new cases of cervical cancer in the United States was 7 per 100,000 women in 2004.

In the United Kingdom, the incidence is 9.1/100,000 per year (2005), similar to the rest of Northern Europe, and mortality is 3.1/100,000 per year (2006) (Cancer Research UK Cervical cancer statistics for the UK). With a 42% reduction from 1988-1997 the NHS implemented screening programme has been highly successful, screening the highest risk age group (2549 years) every 3 years, and those ages 5064 every 5 years.

In Canada, an estimated 1,300 women will be diagnosed with cervical cancer in 2008 and 380 will die.

In Australia, there were 734 cases of cervical cancer (2005).The number of women diagnosed with cervical cancer has dropped on average by 4.5% each year since organised screening began in 1991 (1991-2005)..

Worldwide it is estimated that there are 473,000 cases of cervical cancer, and 253,500 deaths per year.

History

400 BCE - Hippocrates: cervical cancer incurable

1925 - Hans Hinselmann: invented colposcope

1928 - Papanicolaou: developed Pap technique

1941 - Papanicolaou and Trout: Pap screening

1946 - Ayer: spatula to scrape the cervix

1976 - Zur Hausen and Gisam: found HPV DNA in cervical cancer and warts

1988 - Bethesda System for Pap results developed

Epidemiologists working in the early 20th century noted that cervical cancer behaved like a sexually transmitted disease. In summary:

Cervical cancer was common in female sex workers.

It was rare in nuns, except for those who had been sexually active before entering the convent. (Rigoni in 1841)

It was more common in the second wives of men whose first wives had died from cervical cancer.

It was rare in Jewish women.

In 1935, Syverton and Berry discovered a relationship between RPV (Rabbit Papillomavirus) and skin cancer in rabbits. (HPV is species-specific and therefore cannot be transmitted to rabbits)

This led to the suspicion that cervical cancer could be caused by a sexually transmitted agent. Initial research in the 1940s and 1950s put the blame on smegma (e.g. Heins et al. 1958). During the 1960s and 1970s it was suspected that infection with herpes simplex virus was the cause of the disease. In summary, HSV was seen as a likely cause because it is known to survive in the female reproductive tract, to be transmitted sexually in a way compatible with known risk factors, such as promiscuity and low socioeconomic status. Herpes viruses were also implicated in other malignant diseases, including Burkitt's lymphoma, Nasopharyngeal carcinoma, Marek's disease and the Luck renal adenocarcinoma. HSV was recovered from cervical tumour cells.

It was not until the 1980s that human papillomavirus (HPV) was identified in cervical cancer tissue . A description by electron microscopy was given earlier in 1949 and HPV-DNA was identified in 1963. It has since been demonstrated that HPV is implicated in virtually all cervical cancers. Specific viral subtypes implicated are HPV 16, 18, 31, 45 and others.

References and notes

^ a b c d e Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; & Mitchell, Richard N. (2007). Robbins Basic Pathology ((8th ed.) ed.). Saunders Elsevier. pp. 718721. ISBN 978-1-4160-2973-1. 

^ Walboomers JM, Jacobs MV, Manos MM, et al (1999). "Human papillomavirus is a necessary cause of invasive cervical cancer worldwide". J. Pathol. 189 (1): 129. doi:10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F. PMID 10451482. 

^ a b "FDA Licenses New Vaccine for Prevention of Cervical Cancer". U.S. Food and Drug Administration. 2006-06-08. http://www.fda.gov/bbs/topics/NEWS/2006/NEW01385.html. Retrieved 2007-12-02. 

^ a b Lowy DR, Schiller JT (2006). "Prophylactic human papillomavirus vaccines.". J. Clin. Invest. 116 (5): 116773. doi:10.1172/JCI28607. PMID 16670757. PMC 1451224. http://www.jci.org/articles/view/JCI28607. Retrieved 2007-12-01. 

^ "Human Papillomavirus (HPV) Vaccines: Q & A - National Cancer Institute". http://www.cancer.gov/cancertopics/factsheet/risk/HPV-vaccine. Retrieved 2008-07-18. 

^ a b "Cancer Research UK website". http://info.cancerresearchuk.org/cancerstats/types/cervix/incidence/. Retrieved 2009-01-03. 

^ a b c DeMay, M (2007). Practical principles of cytopathology. Revised edition.. Chicago, IL: American Society for Clinical Pathology Press. ISBN 978-0-89189-549-7. 

^ a b c d Canavan TP, Doshi NR (2000). "Cervical cancer.". Am Fam Physician 61 (5): 136976. PMID 10735343. http://www.aafp.org/afp/20000301/1369.html. Retrieved 2007-12-01. 

^ Nanda, Rita (2006-06-09). "Cervical cancer". MedlinePlus Medical Encyclopedia. National Institutes of Health. http://www.nlm.nih.gov/medlineplus/ency/article/000893.htm. Retrieved 2007-12-02. 

^ a b "What Causes Cancer of the Cervix?". American Cancer Society. 2006-11-30. http://www.cancer.org/docroot/CRI/content/CRI_2_2_2X_What_causes_cancer_of_the_cervix_Can_it_be_prevented_8.asp?sitearea=. Retrieved 2007-12-02. 

^ Marrazzo JM, Koutsky LA, Kiviat NB, Kuypers JM, Stine K (2001). "Papanicolaou test screening and prevalence of genital human papillomavirus among women who have sex with women.". Am J Public Health 91 (6): 94752. doi:10.2105/AJPH.91.6.947. PMID 11392939. PMC 1446473. http://www.ajph.org/cgi/pmidlookup?view=long&pmid=11392939. Retrieved 2007-12-30. 

^ "HPV Type-Detect". Medical Diagnostic Laboratories. 2007-10-30. http://www.mdlab.com/html/testing/hpv_typedetect.html. Retrieved 2007-12-02. 

^ Gottlieb, Nicole (2002-04-24). "A Primer on HPV". Benchmarks. National Cancer Institute. http://www.cancer.gov/newscenter/benchmarks-vol2-issue4/page2. Retrieved 2007-12-02. 

^ Muoz N, Bosch FX, de Sanjos S, Herrero R, Castellsagu X, Shah KV, Snijders PJ, Meijer CJ (2003). "Epidemiologic classification of human papillomavirus types associated with cervical cancer.". N. Engl. J. Med. 348 (6): 51827. doi:10.1056/NEJMoa021641. PMID 12571259. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=12571259&promo=ONFLNS19. Retrieved 2007-12-01. 

^ a b Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ, Muoz N (1999). "Human papillomavirus is a necessary cause of invasive cervical cancer worldwide.". J. Pathol. 189 (1): 129. doi:10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F. PMID 10451482. 

^ Snijders PJ, Steenbergen RD, Heideman DA, Meijer CJ (2006). "HPV-mediated cervical carcinogenesis: concepts and clinical implications.". J. Pathol. 208 (2): 15264. doi:10.1002/path.1866. PMID 16362994. 

^ Nader, Carol (2005-02-16). "Expert says circumcision makes sex safer". The Age (Fairfax Media). http://www.theage.com.au/articles/2005/02/15/1108230001471.html. Retrieved 2007-12-02. 

^ Rivet C (2003). "Circumcision and cervical cancer. Is there a link?". Can Fam Physician 49: 10967. PMID 14526861. PMC 2214289. http://www.cfpc.ca/cfp/2003/sep/vol49-sep-critical-1.asp. Retrieved 2007-12-01. 

^ Sherris J. et al. Evidence-Based, Alternative Cervical Cancer Screening Approaches in Low-Resource Settings. International Perspectives on Sexual and Reproductive Health. Volume 35, Number 3, September 2009

^ Sankaranarayanan R et al. A critical assessment of screening methods for cervical neoplasia. International Journal of Gynecology and Obstetrics. 2005;89 Suppl 2:S412.

^ Luciani S, Winkler J. Cervical Cancer prevention in Peru: Lessons learned from the TATI demonstration project. Washington, DC: Pan American Health Organization; 2006.

^ Gage JC, Ferreccio C, Gonzales M, Arroyo R, Huivin M, Robles SC. Follow-up care of women with an abnormal cytology in a low-resource setting. Cancer Detection and Prevention. 2003;27(6):466471.

^ Garcia, Agustin; Omid Hamid, Anthony El-Khoueiry (2006-07-06). "Cervical Cancer". eMedicine. WebMD. http://www.emedicine.com/med/topic324.htm#section~workup. Retrieved 2007-12-02. 

^ Dolinsky, Christopher (2006-07-17). "Cervical Cancer: The Basics". OncoLink (Abramson Cancer Center of the University of Pennsylvania). http://www.oncolink.upenn.edu/types/article.cfm?c=6&s=17&ss=129&id=8226. Retrieved 2007-12-02. 

^ Erstad, Shannon (2007-01-12). "Cone biopsy (conization) for abnormal cervical cell changes". WebMD. http://www.webmd.com/cancer/cervical-cancer/cone-biopsy-conization-for-abnormal-cervical-cell-changes. Retrieved 2007-12-02. 

^ Jones WB, Mercer GO, Lewis JL, Rubin SC, Hoskins WJ (1993). "Early invasive carcinoma of the cervix.". Gynecol. Oncol. 51 (1): 2632. doi:10.1006/gyno.1993.1241. PMID 8244170. http://linkinghub.elsevier.com/retrieve/pii/S0090-8258(83)71241-2. Retrieved 2007-12-01. 

^ Dolson, Laura (2001). "Trachelectomy". http://www.baymoon.com/~gyncancer/library/glossary/bldeftrachelect.htm. Retrieved 2007-12-02. 

^ a b Burnett AF (2006). "Radical trachelectomy with laparoscopic lymphadenectomy: review of oncologic and obstetrical outcomes.". Curr. Opin. Obstet. Gynecol. 18 (1): 813. doi:10.1097/01.gco.0000192968.75190.dc. PMID 16493253. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?an=00001703-200602000-00004. Retrieved 2007-12-01. 

^ Cibula D, Ungr L, Svrovsk J, Zivn J, Freitag P (2005). "[Abdominal radical trachelectomy--technique and experience] [Abdominal radical trachelectomy--technique and experience]" (in Czech). Ceska Gynekol 70 (2): 11722. PMID 15918265. 

^ Plante M, Renaud MC, Hoskins IA, Roy M (2005). "Vaginal radical trachelectomy: a valuable fertility-preserving option in the management of early-stage cervical cancer. A series of 50 pregnancies and review of the literature.". Gynecol. Oncol. 98 (1): 310. doi:10.1016/j.ygyno.2005.04.014. PMID 15936061. http://linkinghub.elsevier.com/retrieve/pii/S0090-8258(05)00270-2. Retrieved 2007-12-01. 

^ Roy M, Plante M, Renaud MC, Ttu B (1996). "Vaginal radical hysterectomy versus abdominal radical hysterectomy in the treatment of early-stage cervical cancer.". Gynecol. Oncol. 62 (3): 3369. doi:10.1006/gyno.1996.0245. PMID 8812529. http://linkinghub.elsevier.com/retrieve/pii/S0090-8258(96)90245-0. Retrieved 2007-12-01. 

^ Dargent D, Martin X, Sacchetoni A, Mathevet P (2000). "Laparoscopic vaginal radical trachelectomy: a treatment to preserve the fertility of cervical carcinoma patients.". Cancer 88 (8): 187782. doi:10.1002/(SICI)1097-0142(20000415)88:8<1877::AID-CNCR17>3.0.CO;2-W. PMID 10760765. 

^ Schlaerth JB, Spirtos NM, Schlaerth AC (2003). "Radical trachelectomy and pelvic lymphadenectomy with uterine preservation in the treatment of cervical cancer.". Am. J. Obstet. Gynecol. 188 (1): 2934. doi:10.1067/mob.2003.124. PMID 12548192. 

^ "FDA Approves First Drug Treatment for Late-Stage Cervical Cancer". U.S. Food and Drug Administration. 2006-06-15. http://www.fda.gov/bbs/topics/NEWS/2006/NEW01391.html. Retrieved 2007-12-02. 

^ Tiro JA, Meissner HI, Kobrin S, Chollette V (2007). "What do women in the U.S. know about human papillomavirus and cervical cancer?". Cancer Epidemiol. Biomarkers Prev. 16 (2): 28894. doi:10.1158/1055-9965.EPI-06-0756. PMID 17267388. http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17267388. Retrieved 2007-12-01. 

^ a b "What Are the Key Statistics About Cervical Cancer?". American Cancer Society. 2008-03-26. http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_are_the_key_statistics_for_cervical_cancer_8.asp?sitearea=. Retrieved 2008-08-19. 

^ Saslow D, Runowicz CD, Solomon D, et al (2002). "American Cancer Society guideline for the early detection of cervical neoplasia and cancer". CA: a cancer journal for clinicians 52 (6): 34262. doi:10.3322/canjclin.52.6.342. PMID 12469763. 

^ Payne N, Chilcott J, McGoogan E (2000). "Liquid-based cytology in cervical screening: a rapid and systematic review". Health technology assessment (Winchester, England) 4 (18): 173. PMID 10932023. http://www.hta.ac.uk/execsumm/summ418.htm. 

^

^ Willis BH, Barton P, Pearmain P, Bryan S, Hyde C (March 2005). "Cervical screening programmes: can automation help? Evidence from systematic reviews, an economic analysis and a simulation modelling exercise applied to the UK". Health technology assessment (Winchester, England) 9 (13): 1207, iii. PMID 15774236. http://www.hta.ac.uk/execsumm/summ913.htm. 

^ Naucler P, Ryd W, Trnberg S, et al (2007). "Human papillomavirus and Papanicolaou tests to screen for cervical cancer" ([dead link]). N. Engl. J. Med. 357 (16): 158997. doi:10.1056/NEJMoa073204. PMID 17942872. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=17942872&promo=ONFLNS19. 

^ http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61248-4/fulltext

^ "EU approves cervical cancer jab". BBC. 2006-09-22. http://news.bbc.co.uk/1/hi/health/5370504.stm. Retrieved 2007-12-02. 

^ "GSK's HPV Vaccine 100% Effective For Four Years, Data Show". Medical News Today (MediLexicon International Ltd). 2006-02-27. http://www.medicalnewstoday.com/articles/38317.php. Retrieved 2007-12-02. 

^ "Cancer jab 'stops 75% of deaths'". BBC. 2006-09-04. http://news.bbc.co.uk/2/hi/health/5311598.stm. Retrieved 2007-12-02. 

^ McNeil C (2006). "Who invented the VLP cervical cancer vaccines?". J. Natl. Cancer Inst. 98 (7): 433. doi:10.1093/jnci/djj144. PMID 16595773. http://jnci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=16595773. Retrieved 2007-12-01. 

^ a b Manhart LE, Koutsky LA. (2002). "Do condoms prevent genital HPV infection, external genital warts, or cervical neoplasia? A meta-analysis.". Sex Transm Dis 29 (11): 72535. 

^ Cornelis J.A. Hogewoning, Maaike C.G. Bleeker, et al. (2003). "Condom use Promotes the Regression of Cervical Intraepithelial Neoplasia and Clearance of HPV: Randomized Clinical Trial". International Journal of Cancer 107 (5): 811816. doi:10.1002/ijc.11474. PMID 14566832. 

^ "Semen 'may fuel cervical cancer'". BBC. 2006-08-31. http://news.bbc.co.uk/2/hi/health/5303054.stm. Retrieved 2007-12-02. 

^ "Semen can worsen cervical cancer". Medical Research Council (UK). http://www.mrc.ac.uk/NewsViewsAndEvents/News/MRC002621. Retrieved 2007-12-02. 

^ American Cancer Society. "What Are the Risk Factors for Cervical Cancer?". http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_cervical_cancer_8.asp. Retrieved 2008-02-21. 

^ a b Sedjo RL, Roe DJ, Abrahamsen M, et al (2002). "Vitamin A, carotenoids, and risk of persistent oncogenic human papillomavirus infection". Cancer Epidemiol. Biomarkers Prev. 11 (9): 87684. PMID 12223432. 

^ a b c Giuliano AR, Siegel EM, Roe DJ, et al (2003). "Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study". J. Infect. Dis. 188 (10): 150816. doi:10.1086/379197. PMID 14624376. 

^ a b Yeo AS, Schiff MA, Montoya G, Masuk M, van Asselt-King L, Becker TM (2000). "Serum micronutrients and cervical dysplasia in Southwestern American Indian women". Nutrition and cancer 38 (2): 14150. doi:10.1207/S15327914NC382_1. PMID 11525590. 

^ Michalsson K, Lithell H, Vessby B, Melhus H. (2003). "Serum Retinol Levels and the Risk of Fracture". NEJM 348 (4): 287294. doi:10.1056/NEJMoa021171. PMID 12540641. 

^ a b Goodman MT, Shvetsov YB, McDuffie K, et al (2007). "Hawaii cohort study of serum micronutrient concentrations and clearance of incident oncogenic human papillomavirus infection of the cervix". Cancer Res. 67 (12): 598796. doi:10.1158/0008-5472.CAN-07-0313. PMID 17553901. http://cancerres.aacrjournals.org/cgi/content/full/67/12/5987. 

^ Kwaniewska A, Tukendorf A, Semczuk M (1997). "Content of alpha-tocopherol in blood serum of human Papillomavirus-infected women with cervical dysplasias". Nutrition and cancer 28 (3): 24851. doi:10.1080/01635589709514583. PMID 9343832. 

^ Piyathilake CJ, Henao OL, Macaluso M, et al (2004). "Folate is associated with the natural history of high-risk human papillomaviruses". Cancer Res. 64 (23): 878893. doi:10.1158/0008-5472.CAN-04-2402. PMID 15574793. http://cancerres.aacrjournals.org/cgi/content/full/64/23/8788. 

^ Kwaniewska A, Tukendorf A, Godzicka-Jzefiak A, Semczuk-Sikora A, Korobowicz E (2002). "Content of folic acid and free homocysteine in blood serum of human papillomavirus-infected women with cervical dysplasia". Eur. J. Gynaecol. Oncol. 23 (4): 3116. PMID 12214730. 

^ Sedjo RL, Papenfuss MR, Craft NE, Giuliano AR (2003). "Effect of plasma micronutrients on clearance of oncogenic human papillomavirus (HPV) infection (United States)". Cancer Causes Control 14 (4): 31926. doi:10.1023/A:1023981505268. PMID 12846362. 

^ Giuliano AR, Papenfuss M, Nour M, Canfield LM, Schneider A, Hatch K (1997). "Antioxidant nutrients: associations with persistent human papillomavirus infection". Cancer Epidemiol. Biomarkers Prev. 6 (11): 91723. PMID 9367065. 

^ "Cervical Cancer". Cervical Cancer: Cancers of the Female Reproductive System: Merck Manual Home Edition. Merck Manual Home Edition. http://www.merck.com/mmhe/sec22/ch252/ch252d.html. Retrieved 2007-03-24. 

^ Committee on Practice Bulletins-Gynecology (2002). "ACOG practice bulletin. Diagnosis and treatment of cervical carcinomas, number 35, May 2002". Obstetrics and gynecology 99 (5 Pt 1): 85567. PMID 11978302. 

^ "Cervical Cancer". Cervical Cancer: Pathology, Symptoms and Signs, Diagnosis, Prognosis and Treatment. Armenian Health Network, Health.am. http://www.health.am/cr/cervical-cancer/. 

^ "Cervical cancer statistics and prognosis". Cancer Research UK. http://www.cancerhelp.org.uk/help/default.asp?page=9260. Retrieved 2007-03-24. 

^ http://www.papscreen.org.au/

^ "WHO Disease and injury country estimates". World Health Organization. 2009. http://www.who.int/healthinfo/global_burden_disease/estimates_country/en/index.html. Retrieved Nov. 11, 2009. 

^ World Health Organization (February 2006). "Fact sheet No. 297: Cancer". http://www.who.int/mediacentre/factsheets/fs297/en/index.html. Retrieved 2007-12-01. 

^ "GLOBOCAN 2002 database: summary table by cancer". http://www-dep.iarc.fr/GLOBOCAN/Table1_sel1.htm. Retrieved 2008-10-26. 

^ SEER cancer statistics

^ http://info.cancerresearchuk.org/cancerstats/types/cervix/mortality/

^ Noni MacDonald, Matthew B. Stanbrook, and Paul C. Hbert (September 9, 2008). "Human papillomavirus vaccine risk and reality [Human papillomavirus vaccine risk and reality.]" (in French). CMAJ 179 (6): 503, 505. doi:10.1503/cmaj.081238. PMID 18762616. PMC 2527393. http://www.cmaj.ca/cgi/content/full/179/6/503. Retrieved 2008-11-17. 

^ http://www.papscreen.org.au/browse.asp?ContainerID=c15

^ "NCCC National Cervical Cancer Coalition". http://www.nccc-online.org/. Retrieved 2008-07-01. 

^ Menczer J (2003). "The low incidence of cervical cancer in Jewish women: has the puzzle finally been solved?" (PDF). Isr. Med. Assoc. J. 5 (2): 1203. PMID 12674663. http://www.ima.org.il/imaj/ar03feb-11.pdf. Retrieved 2007-12-01. 

^ Heins Jr, HC; EJ Dennis, HR Pratt-Thomas (1958-10-01). "The possible role of smegma in carcinoma of the cervix.". American Journal of Obstetrics & Gynecology 76 (4): 72633. PMID 13583012. 

^ Alexander, E.R. (1973-06). "Possible Etiologies of Cancer of the Cervix Other Than Herpesvirus". Cancer Research 33 (6): 1485--90. ISSN 0008-5472. PMID 4352386. http://www.ncbi.nlm.nih.gov/pubmed/4352386. Retrieved 2008-08-06. 

^ Drst, M; L Gissmann, H Ikenberg, H zur Hausen (1983-06). "A Papillomavirus DNA from a Cervical Carcinoma and Its Prevalence in Cancer Biopsy Samples from Different Geographic Regions". Proceedings of the National Academy of Sciences of the United States of America 80 (12): 38125. doi:10.1073/pnas.80.12.3812. ISSN 0027-8424. PMID 6304740. PMC 394142. http://www.ncbi.nlm.nih.gov/pubmed/6304740. Retrieved 2008-08-06. .

Harper DM, Franco EL, Wheeler C, Ferris DG, Jenkins D, Schuind A, Zahaf T, Innis B, Naud P, De Carvalho NS, Roteli-Martins CM, Teixeira J, Blatter MM, Korn AP, Quint W, Dubin G (2004). "Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial.". Lancet 364 (9447): 175765. doi:10.1016/S0140-6736(04)17398-4. PMID 15541448. http://linkinghub.elsevier.com/retrieve/pii/S0140673604173984. Retrieved 2007-12-01. 

Peto, J; C Gilham, O Fletcher, FE Matthews (2004-07-17). "The cervical cancer epidemic that screening has prevented in the UK.". Lancet 364 (9430): 24956. doi:10.1016/S0140-6736(04)16674-9. PMID 15262102. 

External links

Cervical cancer at the Open Directory Project

Cervical cancer at the Yahoo! Directory

v  d  e

Papillomaviridae - Human papillomavirus

Related

diseases

Cervical cancer, HPV-positive oropharyngeal cancer

Factor in other cancers (Anal cancer, Vulvar cancer, Carcinoma of the penis, Head and neck cancer),

Wart (Genital wart, Plantar wart, Verruca plana, Laryngeal papillomatosis), Papilloma, Epidermodysplasia verruciformis

Vaccine

HPV vaccine (Gardasil, Cervarix)

Screening

Pap test - Cytopathology/Cytotechnology results Bethesda System

Colposcopy

Biopsy histology

Cervical intraepithelial neoplasia, Koilocyte

Treatment

Cervical conization, Loop electrical excision procedure

History

Georgios Papanikolaou, Harald zur Hausen

v  d  e

Tumors: urogenital neoplasia  genital neoplasia (C51-C63/D25-29, 179-187/218-222)

Female

Ovaries

Glandular and epithelial

Clear cell adenocarcinoma  Endometrioid tumor

CMS: Krukenberg tumor  Serous cystadenoma/Mucinous cystadenoma  Cystadenocarcinoma/Papillary serous cystadenocarcinoma

Sex cord-gonadal stromal

Leydig cell tumour  Sertoli cell tumour  Sertoli-Leydig cell tumour  Thecoma  Granulosa cell tumour  Luteoma

Connective tissue

Fibroma (Meigs syndrome)  Surface epithelial-stromal tumor (Brenner tumour)

Germ cell

Dysgerminoma  Embryonal carcinoma  Gonadoblastoma  Teratoma  Choriocarcinoma

Fallopian tube

Adenomatoid tumor

Uterus

Myometrium

Uterine fibroids/leiomyoma  Leiomyosarcoma

Endometrium

Endometrioid tumor  Uterine papillary serous carcinoma  Clear cell carcinoma

Cervix

SCC  Cervical intraepithelial neoplasia

General

Uterine sarcoma  Adenomyoma

Vagina

SCC  Botryoid rhabdomyosarcoma  Adenocarcinoma/Clear cell adenocarcinoma  Vaginal intraepithelial neoplasia

Vulva

Papillary hidradenoma  Extramammary Paget's disease  Vulvar intraepithelial neoplasia

Placenta

Choriocarcinoma

Male

Testicles

Sex cord-gonadal stromal

Sertoli-Leydig cell tumour (Sertoli cell tumor, Leydig cell tumor)

Germ cell

G

Seminoma (Spermatocytic seminoma)  Intratubular germ cell neoplasia

NG

Embryonal carcinoma  Endodermal sinus tumor  Gonadoblastoma  Teratoma  Choriocarcinoma  Embryoma

Prostate

Adenocarcinoma  Prostatic intraepithelial neoplasia (HGPIN)  Small cell carcinoma  Transitional cell carcinoma

Penis

Carcinoma (Extramammary Paget's disease)  Bowen's disease  Bowenoid papulosis  Erythroplasia of Queyrat

reproductive system navs: anat female,male/physio/dev, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc

Categories: Sexually transmitted diseases and infections | Viral diseases | Papillomavirus | Gynecological cancerHidden categories: All articles with dead external links | Articles with dead external links from October 2009 | All articles with unsourced statements | Articles with unsourced statements from July 2009 | Articles with unsourced statements from August 2008 | Articles with unsourced statements from January 2009 | Articles with unsourced statements from August 2007